MANSC domain-containing protein 4 (MANSC4)

About MANSC domain-containing protein 4

MANSC domain-containing protein 4 (MANSC4) is a protein from Homo sapiens identified by UniProt accession A6NHS7, 340 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	MANSC domain-containing protein 4
UniProt accession	A6NHS7
Gene	MANSC4
Organism	Homo sapiens
Length	340 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

osteoarthritis, hip · score 0.36
osteoarthritis · score 0.33
vital capacity · score 0.33
blood protein measurement · score 0.30
body height · score 0.29
electrocardiography · score 0.29
PHF-tau measurement · score 0.27
bone density · score 0.25
type 2 diabetes mellitus · score 0.25
osteoarthritis, knee · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NHS7-F1	alphafold	PREDICTED	62.77	—

Amino-acid sequence (340 residues)

MHVAEVAVNV ILLLSMGWTS DSLCSPTIFY RDCWIRRFPG LLINLEESQK LGAQFLKYYS ESTGQKCSRS CCLRKDVSCN LAVFYHSPIH DNINCLHVHC PTLESCILEP GTSAILYNIT DGIDPDLLVF EQSPTYLNTR SSSNRWDRLR ILKAMNLDKQ TTTINGMLPS TEAPSSTTHQ DLVVNTNSTS YSKELTTDFW ARFTSLNESI TTKINKVSPS TDFISNPDNK TISPFFEPID TKLSHMPVPP GLNSSKQLLN KTKGYNSRNH TSANEDEVSV TSKTWLVSVA LCTSVIFLGC CIVILASGCC GKQQGQYKPG QRKSGSLQIK NRNHMKENSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards