About Ankyrin repeat and death domain-containing protein 1B
Ankyrin repeat and death domain-containing protein 1B (ANKDD1B) is a protein
from Homo sapiens identified by UniProt accession
A6NHY2, 528 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | Ankyrin repeat and death domain-containing protein 1B |
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| UniProt accession | A6NHY2 |
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| Gene | ANKDD1B |
|---|
| Organism | Homo sapiens |
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| Length | 528 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (77)
Diseases linked to this target (Open Targets).
- total cholesterol measurement · score 0.39
- body mass index · score 0.39
- type 2 diabetes mellitus · score 0.38
- Drugs used in diabetes use measurement · score 0.36
- low density lipoprotein cholesterol measurement · score 0.34
- self reported educational attainment · score 0.33
- sex hormone-binding globulin measurement · score 0.29
- body fat distribution · score 0.28
- body fat percentage · score 0.27
- obesity · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NHY2-F1 | alphafold | PREDICTED | 83.30 | — |
Amino-acid sequence (528 residues)
MDPAGRARGQ GATAGGLLLR AAAAAKGLRE DLWGAAALPW RSLSRIPKRE GLGEEDTAVA GHELLLPNER SFQNAAKSNN LDLMEKLFEK KVNINVVNNM NRTALHFAVG RNHLSAVDFL LKHKARVDVA DKHGLTVIHL AAWSGSLEVM LMLVKAGADQ RAKNQDGMSA LHFATQSNHV RIVEYLIQDL HLKDLNQPDE KGRKPFLLAA ERGHVEMIEK LTFLNLHTSE KDKGGNTALH LAAKHGHSPA VQVLLAQWQD INEMNELNIS SLQIATRNGH ASLVNFLLSE NVDLHQKVEP KESPLHLVVI NNHITVVNSL LSAQHDIDIL NQKQQTPLHV AADRGNVELV ETLLKAGCDL KAVDKQGKTA LAVASRSNHS LVVGMLIKAE RYYAWREEHH ESIRDPSTGF TLTFKQDHSL ETRHIRTLLW DLAYHQLKAN EWQRLARSWN FTDDQIRAIE EQWSGNESFR EHGHRALLIW LHGTLMTQGD PAKQLYEELV HAGFPKLAEK TRHFKSKTDS NSKKCVVS
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