Leucine-rich repeat-containing protein 14B (LRRC14B)

About Leucine-rich repeat-containing protein 14B

Leucine-rich repeat-containing protein 14B (LRRC14B) is a protein from Homo sapiens identified by UniProt accession A6NHZ5, 514 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 14B
UniProt accession	A6NHZ5
Gene	LRRC14B
Organism	Homo sapiens
Length	514 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
DNA methylation · score 0.06
Tetralogy of Fallot · score 0.01
non-small cell lung carcinoma · score 0.01
small cell lung carcinoma · score 0.01
osteogenesis imperfecta · score 0.00
cardiac hypertrophy · score 0.00
Treacher-Collins syndrome · score 0.00
glaucoma · score 0.00
Crohn's disease · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NHZ5-F1	alphafold	PREDICTED	91.78	—

Amino-acid sequence (514 residues)

MDTMRSLRFI SAEALVSHPQ VARQSLDSVA HNLYPLLFKA SYLLEQAEVT RAVLGRWPLE EFRLGALLGP GADHPQDLRD RTCRACLEAL VRGLADHVLQ DRSRRRLRVA DLTGIRDVQV QRCPCGRALG RWGRTQLLAR TCCELQAEPL AAGRPVEVLA DLFVTEGNFE AVVQALRPAG PAPLRVHCPS FRADSLSPSQ LLHVLRLAGP GALRKLEVVH NVRLHAGHVQ QLLAQVGFPR LASLTLPTKA FDAPPTYAST PDGEDPLLAS IARELSKMAQ LTELSVAFST LTGKIPTLLG PLQTPLRVLD LANCALNHTD MAFLADCAHA AHLEVLDLSG HNLVSLYPST FFRLLSQASR TLRILTLEEC GIVDSHVGML ILGLSPCHRL RQLKFLGNPL SARALRRLFT ALCELPELRC IEFPVPKDCY PEGAAYPQDE LAMSKFNQQK YDEIAEELRA VLLRADREDI QVSTPLFGSF DPDIQETSNE LGAFLLQAFK TALENFSRAL KQIE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards