Wilms tumor protein 1-interacting protein (WTIP)

About Wilms tumor protein 1-interacting protein

Wilms tumor protein 1-interacting protein (WTIP) is a protein from Homo sapiens identified by UniProt accession A6NIX2, 430 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	Wilms tumor protein 1-interacting protein
UniProt accession	A6NIX2
Gene	WTIP
Organism	Homo sapiens
Length	430 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
breast adenocarcinoma · score 0.18
non-small cell lung carcinoma · score 0.08
acute myeloid leukemia · score 0.07
nephrotic syndrome · score 0.07
familial idiopathic steroid-resistant nephrotic syndrome · score 0.07
focal segmental glomerulosclerosis · score 0.07
proteinuria, chronic benign · score 0.06
nail-patella-like renal disease · score 0.06
nephrotic syndrome 16 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NIX2-F1	alphafold	PREDICTED	64.12	—

Amino-acid sequence (430 residues)

MQRSRAGADE AALLLAGLAL RELEPGCGSP GRGRRGPRPG PGDEAAPALG RRGKGSGGPE AGADGLSRGE RGPRRAAVPE LSAQPAGSPR ASLAGSDGGG GGGSARSSGI SLGYDQRHGS PRSGRSDPRP GPGPPSVGSA RSSVSSLGSR GSAGAYADFL PPGACPAPAR SPEPAGPAPF PLPALPLPPG REGGPSAAER RLEALTRELE RALEARTARD YFGICIKCGL GIYGAQQACQ AMGSLYHTDC FTCDSCGRRL RGKAFYNVGE KVYCQEDFLY SGFQQTADKC SVCGHLIMEM ILQALGKSYH PGCFRCSVCN ECLDGVPFTV DVENNIYCVR DYHTVFAPKC ASCARPILPA QGCETTIRVV SMDRDYHVAC YHCEDCGLQL SGEEGRRCYP LAGHLLCRRC HLRRLQPGPL PSPTVHVTEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards