About Homeobox protein Nkx-6.3
Homeobox protein Nkx-6.3 (NKX6-3) is a protein
from Homo sapiens identified by UniProt accession
A6NJ46, 265 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Homeobox protein Nkx-6.3 |
|---|
| UniProt accession | A6NJ46 |
|---|
| Gene | NKX6-3 |
|---|
| Organism | Homo sapiens |
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| Length | 265 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.44
- reticulocyte count · score 0.40
- mean corpuscular hemoglobin concentration · score 0.38
- HbA1c measurement · score 0.34
- reticulocyte measurement · score 0.34
- Drugs used in diabetes use measurement · score 0.33
- diabetes mellitus · score 0.31
- mean corpuscular volume · score 0.29
- Red cell distribution width · score 0.29
- mean reticulocyte volume · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NJ46-F1 | alphafold | PREDICTED | 63.18 | — |
Amino-acid sequence (265 residues)
MESNLQGTFL LNNTPLAQFP EMKAPVCQYS VQNSFYKLSP PGLGPQLAAG TPHGITDILS RPVAAPNNSL LSGYPHVAGF GGLSSQGVYY SPQVGNFSKA GNEYPTRTRN CWADTGQDWR GGRQCSNTPD PLSDSIHKKK HTRPTFTGHQ IFALEKTFEQ TKYLAGPERA RLAYSLGMTE SQVKVWFQNR RTKWRKKSAL EPSSSTPRAP GGAGAGAGGD RAPSENEDDE YNKPLDPDSD DEKIRLLLRK HRAAFSVLSL GAHSV
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