About Nuclear pore complex-interacting protein family member B2
Nuclear pore complex-interacting protein family member B2 (NPIPB2) is a protein
from Homo sapiens identified by UniProt accession
A6NJ64, 397 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Nuclear pore complex-interacting protein family member B2 |
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| UniProt accession | A6NJ64 |
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| Gene | NPIPB2 |
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| Organism | Homo sapiens |
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| Length | 397 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (30)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.34
- reticulocyte measurement · score 0.33
- systolic blood pressure · score 0.24
- gastric carcinoma · score 0.19
- body height · score 0.16
- neurofibrillary tangles measurement · score 0.15
- heel bone mineral density · score 0.15
- metabolite measurement · score 0.13
- bone quantitative ultrasound measurement · score 0.13
- Immature Reticulocyte Fraction Measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NJ64-F1 | alphafold | PREDICTED | 55.98 | — |
Amino-acid sequence (397 residues)
MFCCLGYEWL SGGCKTWHSA WVINTLADHH HRGTDFGGSP WLRIIIAFPR SYKVVLTLWT VYLWLSFLKT IFQSENGHDV STDVQQRARR SNRRRQEGLR SICMHTKKRV SSFPGNKIGL KDVITLRRHV ETKGRAKIRK MKVTTKINHH DKINGKRKTA KKQKLSVKEC EHAEKERQVS EAEENGKLDM KEIHTYMKMF QRAQELRRRA EDYHKCKIPP SARKALCNWV RMAAAEHRHS SGLPYWPYLT AETLKNRMGH QPPPPTQQHS ITDNSLSLKT PPECLLTPLP PSADDNLKTP PECLLTPLPP SAPPSADDNL KTPPLATQEA EAEKPPKPKR WRAAEMESPP EPKRRRAAEV ESPPEPKRRR AAEVEPSSPE PKRRRLSKLR TGHCTQA
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