About 12S rRNA N(4)-cytidine methyltransferase METTL15
12S rRNA N(4)-cytidine methyltransferase METTL15 (METTL15) is a protein
from Homo sapiens identified by UniProt accession
A6NJ78, 407 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | 12S rRNA N(4)-cytidine methyltransferase METTL15 |
|---|
| UniProt accession | A6NJ78 |
|---|
| Gene | METTL15 |
|---|
| Organism | Homo sapiens |
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| Length | 407 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (77)
Diseases linked to this target (Open Targets).
- sleep duration · score 0.29
- creatinine measurement · score 0.29
- aspartate aminotransferase measurement · score 0.29
- age at menarche · score 0.27
- body height · score 0.24
- cystatin C measurement · score 0.24
- triglyceride measurement · score 0.24
- systolic blood pressure · score 0.22
- IGF-1 measurement · score 0.22
- wellbeing measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NJ78-F1 | alphafold | PREDICTED | 80.71 | — |
Amino-acid sequence (407 residues)
MLRYPYFCRM YKECLSCWLE SGIPNLGVWP NRIHTTAEKY REYEAREQTD QTQAQELHRS QDRDFETMAK LHIPVMVDEV VHCLSPQKGQ IFLDMTFGSG GHTKAILQKE SDIVLYALDR DPTAYALAEH LSELYPKQIR AMLGQFSQAE ALLMKAGVQP GTFDGVLMDL GCSSMQLDTP ERGFSLRKDG PLDMRMDGGR YPDMPTAADV VNALDQQALA SILRTYGEEK HAKKIASAIV QARSIYPITR TQQLASIVAG AFPPSAIYTR KDLLQRSTHI ATKTFQALRI FVNNELNELY TGLKTAQKFL RPGGRLVALS FHSLEDRIVK RFLLGISMTE RFNLSVRQQV MKTSQLGSDH ENTEEVSMRR APLMWELIHK KVLSPQDQDV QDNPRGRSAK LRAAIKL
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