Proline-rich protein 19 (PRR19)

About Proline-rich protein 19

Proline-rich protein 19 (PRR19) is a protein from Homo sapiens identified by UniProt accession A6NJB7, 356 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.

Target properties

Protein name	Proline-rich protein 19
UniProt accession	A6NJB7
Gene	PRR19
Organism	Homo sapiens
Length	356 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (103)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.07
partial chromosome Y deletion · score 0.07
spermatogenic failure 65 · score 0.06
spermatogenic failure, X-linked, 3 · score 0.06
congenital bilateral absence of vas deferens · score 0.06
spermatogenic failure 56 · score 0.06
spermatogenic failure 39 · score 0.06
spermatogenic failure 25 · score 0.06
spermatogenic failure 72 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NJB7-F1	alphafold	PREDICTED	52.76	—

Amino-acid sequence (356 residues)

MDTQGPVSQP FQQPEKPGRV RRRKTRRERN KALVGSRRPL AHHDPPVAIR DPPVVPTASK LVVITQGRLS REHRGLFNHE VKSLDVARLL SSGTLVPGSP TLPAKPSPSP GRAQEPAPRS RDKENQVPGG SGPGPPSSPE LSGVGQLLAE LQCQLSLPQA FPRRNLIQDA RDAIVHTLQA CHGCVPDLAL VLRGCQPPLP GAKPGVSERK MTPFWINSPD QVPEQERQRK QQGTKEFTFP MPYTSSMPTA HRGSLAPPRG PWPPYFPSLS SPSGTAWGPP TAFDLLKSIW LVATPPPPRP WGVGLPQPLP QPSSPLLPRT SVLDWSPSPP SPLPSLSWVV AQSSPEAWSF PPMRLY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards