Homeobox protein unc-4 homolog (UNCX)

About Homeobox protein unc-4 homolog

Homeobox protein unc-4 homolog (UNCX) is a protein from Homo sapiens identified by UniProt accession A6NJT0, 531 residues long. MolForge cross-references it against 0 known binders and 163 disease associations.

Target properties

Protein name	Homeobox protein unc-4 homolog
UniProt accession	A6NJT0
Gene	UNCX
Organism	Homo sapiens
Length	531 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (163)

Diseases linked to this target (Open Targets).

glomerular filtration rate · score 0.44
creatinine measurement · score 0.43
blood urea nitrogen measurement · score 0.41
lean body mass · score 0.40
erythrocyte count · score 0.39
age at first sexual intercourse measurement · score 0.38
urate measurement · score 0.38
uric acid measurement · score 0.37
hemoglobin measurement · score 0.36
body height · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NJT0-F1	alphafold	PREDICTED	57.42	—

Amino-acid sequence (531 residues)

MMDGRLLEHP HAQFGGSLGG VVGFPYPLGH HHVYELAGHQ LQSAAAAASV PFSIDGLLGG SCAAAASVVN PTPLLPAACG VGGDGQPFKL SDSGDPDKES PGCKRRRTRT NFTGWQLEEL EKAFNESHYP DVFMREALAL RLDLVESRVQ VWFQNRRAKW RKKENTKKGP GRPAHNSHPT TCSGEPMDPE EIARKELEKM EKKKRKHEKK LLKSQGRHLH SPGGLSLHSA PSSDSDSGGG GLSPEPPEPP PPAAKGPGAH ASGAAGTAPA PPGEPPAPGT CDPAFYPSQR SGAGPQPRPG RPADKDAASC GPGAAVAAVE RGAAGLPKAS PFSVESLLSD SPPRRKAASN AAAAAAAGLD FAPGLPCAPR TLIGKGHFLL YPITQPLGFL VPQAALKGGA GLEPAPKDAP PAPAVPPAPP AQASFGAFSG PGGAPDSAFA RRSPDAVASP GAPAPAPAPF RDLASAAATE GGGGDCADAG TAGPAPPPPA PSPRPGPRPP SPAEEPATCG VPEPGAAAGP SPPEGEELDM D

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards