Leucine-rich repeat-containing protein 3C (LRRC3C)

About Leucine-rich repeat-containing protein 3C

Leucine-rich repeat-containing protein 3C (LRRC3C) is a protein from Homo sapiens identified by UniProt accession A6NJW4, 275 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 3C
UniProt accession	A6NJW4
Gene	LRRC3C
Organism	Homo sapiens
Length	275 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.18
total blood protein measurement · score 0.14
ulcerative colitis · score 0.11
asthma · score 0.10
sum of basophil and neutrophil counts · score 0.08
leukocyte count · score 0.06
sum of neutrophil and eosinophil counts · score 0.06
systemic scleroderma · score 0.05
childhood onset asthma · score 0.05
cystatin C measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NJW4-F1	alphafold	PREDICTED	78.98	—

Amino-acid sequence (275 residues)

MRMTSSSFVS YCTPGLCQFM AMLPTAGHLL PLLLVIGTGG TVPSPQVPPR GCYVAKEAGE RTFRCSQAGL SAVPSGIPND TRKLYLDANQ LASVPAGAFQ HLPVLEELDL SHNALAHLSG AAFQGLEGTL RHLDLSANQL ASVPVEAFVG LQIQVNLSAN PWHCDCALQE VLRQVRLVPG TGTGIVCGSG ARPDLVGQEF LLLAGEEELC GSGWGGARRS TDVALLVTMG GWLTLMVAYL VHYVWQNRDE TRRSLKRAPV LPVRSEDSSI LSTVV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards