T-cell surface glycoprotein CD8 beta-2 chain (CD8B2)

About T-cell surface glycoprotein CD8 beta-2 chain

T-cell surface glycoprotein CD8 beta-2 chain (CD8B2) is a protein from Homo sapiens identified by UniProt accession A6NJW9, 210 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.

Target properties

Protein name	T-cell surface glycoprotein CD8 beta-2 chain
UniProt accession	A6NJW9
Gene	CD8B2
Organism	Homo sapiens
Length	210 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (95)

Diseases linked to this target (Open Targets).

Okt4 epitope deficiency · score 0.08
combined immunodeficiency with skin granulomas · score 0.07
severe combined immunodeficiency due to IKK2 deficiency · score 0.07
severe combined immunodeficiency due to CARD11 deficiency · score 0.07
common variable immunodeficiency · score 0.07
immunodeficiency 79 · score 0.07
Alymphoid cystic thymic dysgenesis · score 0.07
X-Linked Combined Immunodeficiency Diseases · score 0.07
immunodeficiency 18 · score 0.07
22q11.2 deletion syndrome · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NJW9-F1	alphafold	PREDICTED	81.46	—

Amino-acid sequence (210 residues)

MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM CIYWLRQRQA PSSDSHHEFL TLWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP VTLGLLVAGV LVLLVSLGVA MHLCCRRRRA RLRFMKQFYK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards