Glyoxalase domain-containing protein 5 (GLOD5)

About Glyoxalase domain-containing protein 5

Glyoxalase domain-containing protein 5 (GLOD5) is a protein from Homo sapiens identified by UniProt accession A6NK44, 160 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	Glyoxalase domain-containing protein 5
UniProt accession	A6NK44
Gene	GLOD5
Organism	Homo sapiens
Length	160 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
Barrett's esophagus · score 0.04
clear cell renal carcinoma · score 0.02
hepatocellular carcinoma · score 0.01
ulcerative colitis · score 0.01
cancer · score 0.00
cystic fibrosis · score 0.00
Leishmaniasis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NK44-F1	alphafold	PREDICTED	90.05	—

Amino-acid sequence (160 residues)

MLRHLPSRLP VKMWGRTLEK QSWRDSSQTP PPCLIRRLDH IVMTVKSIKD TTMFYSKILG MEVMTFKEDR KALCFGDQKF NLHEVGKEFE PKAAHPVPGS LDICLITEVP LEEMIQHLKA CDVPIEEGPV PRTGAKGPIM SIYFRDPDRN LIEVSNYISS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards