About Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial
Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial (LIPT2) is a protein
from Homo sapiens identified by UniProt accession
A6NK58, 231 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial |
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| UniProt accession | A6NK58 |
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| Gene | LIPT2 |
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| Organism | Homo sapiens |
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| Length | 231 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (56)
Diseases linked to this target (Open Targets).
- Osteopetrosis with renal tubular acidosis · score 0.67
- early-onset progressive encephalopathy-hearing loss-pons hypoplasia-brain atrophy syndrome · score 0.12
- hemoglobin measurement · score 0.09
- cancer · score 0.08
- neoplasm · score 0.08
- colorectal cancer · score 0.07
- hematocrit · score 0.05
- colorectal adenoma · score 0.05
- grip strength measurement · score 0.05
- body height · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NK58-F1 | alphafold | PREDICTED | 93.05 | — |
Amino-acid sequence (231 residues)
MRQPAVRLVR LGRVPYAELL GLQDRWLRRL QAEPGIEAPS GTEAGALLLC EPAGPVYTAG LRGGLTPEET ARLRALGAEV RVTGRGGLAT FHGPGQLLCH PVLDLRRLGL RLRMHVASLE ACAVRLCELQ GLQDARARPP PYTGVWLDDR KICAIGVRCG RHITSHGLAL NCSTDLTWFE HIVPCGLVGT GVTSLSKELQ RHVTVEEVMP PFLVAFKEIY KCTLISEDSP N
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