About Ankyrin repeat and SOCS box protein 14
Ankyrin repeat and SOCS box protein 14 (ASB14) is a protein
from Homo sapiens identified by UniProt accession
A6NK59, 587 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Ankyrin repeat and SOCS box protein 14 |
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| UniProt accession | A6NK59 |
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| Gene | ASB14 |
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| Organism | Homo sapiens |
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| Length | 587 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (15)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.49
- IGF-1 measurement · score 0.23
- insulin like growth factor measurement · score 0.23
- pancreatic adenocarcinoma · score 0.18
- vital capacity · score 0.09
- appendicular lean mass · score 0.09
- diastolic blood pressure · score 0.06
- monocyte percentage of leukocytes · score 0.04
- Tetralogy of Fallot · score 0.02
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NK59-F1 | alphafold | PREDICTED | 86.34 | — |
Amino-acid sequence (587 residues)
MDNYTSDEDI DEDFDTQLII QQSLQDIYKP GTAQHAPKDE SLHSFLSADY KKIVETIEKV GKEDALSHLT KYHSAFGEAD EIGWIPLHKA AVQLNRKILE ITLSASDPSL WEQTTHNGET PLFLAVSSCL LENATFLLLN GCNPNAKNFE GNSPLLAAVL RDCYDMAALL INYGADVNLR CANERTALHE AAKLGREDMV KLMLVSGAHP DPQSTYGFTP LALAAQSGHT EIMEMLLRKG KIFCLASDSS SILLEAASGG NPDAVALLLE YGADANIPKN SGHLPIHVAA DRGHLLALKI LIPVTDLAAI KQSGISPVHC AAAGAHPQCL ELLIQAGFDV NFMLDQRINK HYDDHRKSAL YFAVSNSDLS SVKLLLSAGA LPNQDPVNCL QIALRMGNYE LISLLLRHGA NVNYFCRVNP LHFPSALQYT LKDEVMLRML LNYGYDTERC FDCPHGDKVH PSYTVEGWTS TVIKDTKFCE VITLSWLQHL SGKVVRVMLD YVDQVRICSK LKAVLQKQGI WSEIHFILTN PRSLKHLCRL KIRKCMGRLH LRCPVFMSFL PLPNRLKAYV LYKEYDLYGQ GIFTGTW
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