Ras association domain-containing protein 10 (RASSF10)

About Ras association domain-containing protein 10

Ras association domain-containing protein 10 (RASSF10) is a protein from Homo sapiens identified by UniProt accession A6NK89, 507 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.

Target properties

Protein name	Ras association domain-containing protein 10
UniProt accession	A6NK89
Gene	RASSF10
Organism	Homo sapiens
Length	507 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (103)

Diseases linked to this target (Open Targets).

chronic obstructive pulmonary disease · score 0.37
FEV/FVC ratio · score 0.32
smoking status measurement · score 0.32
acne · score 0.30
peak expiratory flow · score 0.20
self reported educational attainment · score 0.13
neutrophil count · score 0.11
neoplasm · score 0.11
hepatocellular carcinoma · score 0.10
cancer · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NK89-F1	alphafold	PREDICTED	71.51	—

Amino-acid sequence (507 residues)

MDPSEKKISV WICQEEKLVS GLSRRTTCSD VVRVLLEDGC RRRRRQRRSR RLGSAGDPHG PGELPEPPNE DDEDDDEALP QGMLCGPPQC YCIVEKWRGF ERILPNKTRI LRLWAAWGEE QENVRFVLVR SEASLPNAGP RSAEARVVLS RERPCPARGA PARPSLAMTQ EKQRRVVRKA FRKLAKLNRR RQQQTPSSCS STSSSTASSC SSSPRTHESA SVERMETLVH LVLSQDHTIR QQVQRLHELD REIDHYEAKV HLDRMRRHGV NYVQDTYLVG AGIELDGSRP GEEPEEVAAE AEEAAAAPPL AGEAQAAALE ELARRCDDLL RLQEQRVQQE ELLERLSAEI QEELNQRWMR RRQEELAARE EPLEPDGGPD GELLLEQERV RTQLSTSLYI GLRLNTDLEA VKSDLDYSQQ QWDSKKRELQ GLLQTLHTLE LTVAPDGAPG SGSPSREPGP QACADMWVDQ ARGLAKSGPG NDEDSDTGLS SMHSQDSDSL PMCESLV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards