SH2 domain-containing protein 7 (SH2D7)

About SH2 domain-containing protein 7

SH2 domain-containing protein 7 (SH2D7) is a protein from Homo sapiens identified by UniProt accession A6NKC9, 451 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	SH2 domain-containing protein 7
UniProt accession	A6NKC9
Gene	SH2D7
Organism	Homo sapiens
Length	451 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

calcium measurement · score 0.16
total blood protein measurement · score 0.15
serum albumin measurement · score 0.08
hematocrit · score 0.07
erythrocyte count · score 0.04
hemoglobin measurement · score 0.03
Red cell distribution width · score 0.03
protein measurement · score 0.02
diet measurement · score 0.02
ulcerative colitis · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NKC9-F1	alphafold	PREDICTED	57.10	—

Amino-acid sequence (451 residues)

MEDSLKQLSL GRDPEGAGDS QALAELQELA LKWFMETQAP FILQNGALPP WFHGFITRKQ TEQLLRDKAL GSFLIRLSDR ATGYILSYRG SDRCRHFVIN QLRNRRYIIS GDTQSHSTLA ELVHHYQEAQ LEPFKEMLTA ACPRPEDNDL YDAITRGLHQ TIVDPENPPA TAFLTVVPDK AASPRSSPKP QVSFLHAQKS LDVSPRNLSQ EESMEAPIRV SPLPEKSSSL LEESFGGPSD IIYADLRRMN QARLGLGTEG SGRHGPVPAG SQAYSPGREA QRRLSDGEQN RPDGLGPVLS GVSPDQGPTE SPTSWGCSDA MGSLGATWRQ EFPKLSQEAQ PCSQGSSADI YEFIGTEGLL QEARDTPDQE GSTYEQIPAC WGGPARAPHP GASPTYSPWV HGYKRISGTP ELSEPGNTYE QIPATKSKET GRTHKPDKLR RLFFTYRKHK F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards