Retrotransposon-like protein 1 (RTL1)

About Retrotransposon-like protein 1

Retrotransposon-like protein 1 (RTL1) is a protein from Homo sapiens identified by UniProt accession A6NKG5, 1358 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	Retrotransposon-like protein 1
UniProt accession	A6NKG5
Gene	RTL1
Organism	Homo sapiens
Length	1358 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (88)

Diseases linked to this target (Open Targets).

body height · score 0.46
type 1 diabetes mellitus · score 0.44
forced expiratory volume · score 0.42
diabetes mellitus · score 0.40
vital capacity · score 0.39
complication · score 0.34
age at menarche · score 0.34
body mass index · score 0.33
glucose measurement · score 0.31
breast fibrocystic disease · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NKG5-F1	alphafold	PREDICTED	58.17	—

Amino-acid sequence (1358 residues)

MIEPSEDSFE TMMEHKNPSS KQMESSEGSS NTTEATSGSG VRGEAGPASG PAQEKKEPPS GPLQEMEELP TDLLQDMEEP SSGPRKEIED PPNDLLQDLE ESCNGSHQAR GDPLSGASDR MKEASVNPSG AREEQEAHTD LKESGREETP QEQNQTEHST AELMAMVRSI ISLYFRMQDL KEQQRVAEEI LIKGINAGQL PAPKHFSGDR REFHEFIVLC QLTLQSYPRM FYNDRLRVGY VINHLSGLAL EWAKALLQEN SPLIGDFPAF LEAMSEVFEY RQALRVAEEA MFTIRQGGRS ATEYIDEFQS LVPILGWPDE VLQAHLCQGL NEEIRHYLFR VPQPDSLDSL IVLILQIEEK LAERRAMLRL PPEARPRNLT WIDSPAPERW MVSSWLPSEV HPDINRAHLF LLLMVRVNPY HSVAVQALVD SGADGNFMDE KFAQEHYVEL YEKPYPQPVQ SVDGSLIGNE PVWLYTEPLV CIHQNHQESI EFDIVPSPNF SVVLGIRWLR VHAPEVDWIK GRCTFHSPYC LKNCFRPPPP CIALERHGMS LLPGLPHPYS DLADVFNPKE ADDETSDQPS SDGSDDLSES EPSELQQAGD SDHSETFYEC PSTAPWEPVG ARMQERARLQ EEYWDLQDML TNRQDYIQMI PELFDQLHGA EWFTKLELRG TIVEESVNGH RTEDVWKAAF GLELEEMKSY QPFALSPDPI IPQNVIHFIL KDMLGFFVLS YGQEVLIYSM SQEEHLHHVR QVLVRFRHHN VYCSLDKSQF HRQTVEFLGF VVTPKGVKLN KNVMTIITGY PTPGSKLSLR NFIEFVFPYR HFVERFSIIA EPLVRQLLSS YQFYWGVEEQ EAFECLKRAF RKAPLLHHPK PQNPFYLETG VTGTALHASL IQIDDQTGKR ACCAFYSRNI SPIEVEYSQA EMKILPIRAA FMVWCRYLEN TEEPIMILLN TEDLASLNND RLTVLLPGHW VFFFSHFNFD VMELPEQDGG RALPPVRNLR WRRAFQRNTA ARQTLLLASR GFPRDPSTES GEEENEEQDE LNEQILRQEL LAMIPIDQIL NSFLAHFSMA QIRAVILHFF RGLLYWKNTL ALAAILVLLR VRQCLSLRPA PAMRVARPQP QRSLRLILDS SLIAGSSITT AITQLLTQMP ALVGANTIPA QELAELFLGP GRWQRNALHS QAHRGLQFTP GFWLTLCEFF GVRVTPQEGH LPALRQNRYL ELHVVGDEDV VLREALQDDL QRYRQCGLHD GLQDTSQDKQ DNDVQEAPPS HTAATHPPRP RHLMDPQVLE FLGSRLLHIH SADGQLHLLS REQAARALSQ FLTLIYRRAL PIPAWESQPR EQARLEELPD EDEDANLD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards