About Putative short-chain dehydrogenase/reductase family 42E member 2
Putative short-chain dehydrogenase/reductase family 42E member 2 (SDR42E2) is a protein
from Homo sapiens identified by UniProt accession
A6NKP2, 422 residues long.
MolForge cross-references it against 0 known binders and
2 disease associations.
Target properties
| Protein name | Putative short-chain dehydrogenase/reductase family 42E member 2 |
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| UniProt accession | A6NKP2 |
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| Gene | SDR42E2 |
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| Organism | Homo sapiens |
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| Length | 422 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (2)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- heel bone mineral density · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NKP2-F1 | alphafold | PREDICTED | 86.38 | — |
Amino-acid sequence (422 residues)
MKSNPPRSSL EACKAAGQAP QQKTQAKPTK AARQKVLVTG GGGYLGFSLG SHLAKSGTSV ILLDRRRPQW ELSPETKFIQ ADVRDEEALY RAFEGVDCVF HVASYGMSGA EKLQKEQIES INVGGTKLVI DVCVRRRVPR LIYTSTVNVA FGGKPIEQGD EDSVPYFPLD EHVDHYSRTK AIADQLTLMA NGMPLPGGGT LRTCVLRPPG IYGPEEQRHL PRVAGHIKKR LFMFRFGDHK ARMNWVHVHN LVQAHVLAAE ALTTAKGYVA SGQAYYINDG ESVNLFEWMA PLFEKLGYSQ PWIQVPTSWV YLTAAVMERL HLALRPICSL PPLLTRSEVR SVAVTHTFQI AKARAQLGYA PDKFRFADAV ELYVQSTTRR PRGSTARTLL RLLLRLLLFL GLLALALHFL GLQPLHAAVE RL
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