About RanBP2-like and GRIP domain-containing protein 3
RanBP2-like and GRIP domain-containing protein 3 (RGPD3) is a protein
from Homo sapiens identified by UniProt accession
A6NKT7, 1758 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | RanBP2-like and GRIP domain-containing protein 3 |
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| UniProt accession | A6NKT7 |
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| Gene | RGPD3 |
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| Organism | Homo sapiens |
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| Length | 1758 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (152)
Diseases linked to this target (Open Targets).
- hepatocellular carcinoma · score 0.36
- melanoma · score 0.23
- squamous cell lung carcinoma · score 0.21
- breast carcinoma · score 0.20
- colorectal adenocarcinoma · score 0.19
- T-cell acute lymphoblastic leukemia · score 0.18
- oral squamous cell carcinoma · score 0.18
- gastric carcinoma · score 0.18
- astrocytoma · score 0.18
- acute myeloid leukemia · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NKT7-F1 | alphafold | PREDICTED | 66.54 | — |
Amino-acid sequence (1758 residues)
MSCSKAYGER YVASVQGSAP SPRKKSTRGF YFAKLYYEAK EYDLAKKYIC TYINVREMDP RAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI AELLCKNDVT DGRAEYWVER AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL FDLIQSELYV RPDDVHVNIR LVELYRSTKR LKDAVARCHE AERNIALRSS LEWNSCVVQT LKEYLESLQC LESDKSDWRA TNTDLLLAYA NLMLLTLSTR DVQESRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMHAGSLLLK MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLIKGEAG QNLLEMMACD RLSQSGHMLL NLSRGKQDFL KVVVETFANK SGQSALYDAL FSSQSPKDTS FLGSDDIGNI DVQEPELEDL ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA LPGIRKWLKQ LFHHLPQETS RLETNAPESI CILDLEVFLL GVVYTSHLQL KEKCNSHHSS YQPLCLPLPV CKQLCTERQK SWWDAVCTLI HRKAVPGNSA KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KCLQKMGSGL NSFYDQREYI GRSVHYWKKV LPLLKIIKKK NSIPEPIDPL FKHFHSVDIQ ASEIVEYEED AHVTFAILDA VNGNIEDAMT AFESIKSVVS YWNLALIFHR KAEDIANDAL SPEEQEECKN YLRKTRGYLI KILDDSDSNL SVVKKLPVPL ESVKEMLKSV MQELENYSEG GPLYKNGSLR NADSEIKHST PSPTKYSLSP SKSYKYSPKT PPRWAEDQNS LLKMIRQEVK AIKEEMQELK LNSSKSASHH RWPTENYGPD SVPDGYQGSQ TFHGAPLTVA TTGPSVYYSQ SPAYNSQYLL RPAANVTPTK GSSNTEFKST KEGFSIPVSA DGFKFGISEP GNQEKKSEKP LENDTGLQAQ DISGRKKGRG VIFGQTSSTF TFADVAKSTS GEGFQFGKKD LNFKGFSGAG EKLFSSQYGK MANKANTSGD FEKDDDAYKT EDSDDIHFEP VVQMPEKVEL VTGEEGEKVL YSQGVKLFRF DAEVSQWKER GLGNLKILKN EVNGKVRMLM QREQVLKVCA NHWITTTMNL KPLSGSDRAW MWSASDFSDG DAKLERLAAK FKTPELAEEF KQKFEECQRL LLDIPLQTPH KLVDTGRAAK LIQRAEEMKS GLKDFKTFLT NDQTKVAEEE NKGSGTGAAG ASDTTIKPNA ENTGPTLEWD NYDLREDALD DSVSSSSVHA SPLASSPVRK NLFHFDESTT GSNFSFKSAL SLSKSPAKLN QSGTSVGTDE ESDVTQEEER DGQYFEPVVP LPDLVEVSSG EENEQVVFSH RAEFYRYDKD VGQWKERGIG DIKILQNYDN KHVRILMRRD QVLKLCANHR ITPDMSLQNM KGTERVWVWT ACDFADGERK VEHLAVRFKL QDVADSFKKI FDEAKTAQEK DSLITPHVSR SSTPRESPCG KIAVAVLEET TRERTDVIQG DDVADAASEV EVSSTSETTT KAVVSPPKFV FGSESVKRIF SSEKSKPFAF GNSSATGSLF GFSFNAPLKS NNSETSSVAQ SGSESKVEPK KCELSKNSDI EQSSDSKVKN LSASFPTEES SINYTFKTPE KEPPLWYAEF TKEELVQKLS STTKSADHLN GLLREIEATN AVLMEQIKLL KSEIRRLERN QEQEVSAANV EHLKNVLLQF IFLKPGSERE RLLPVINTML QLSLEEKGKL AAVAQGEE
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