About Protein shisa-7
Protein shisa-7 (SHISA7) is a protein
from Homo sapiens identified by UniProt accession
A6NL88, 538 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Protein shisa-7 |
|---|
| UniProt accession | A6NL88 |
|---|
| Gene | SHISA7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 538 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (87)
Diseases linked to this target (Open Targets).
- Young adult-onset Parkinsonism · score 0.05
- Huntington disease-like syndrome due to C9ORF72 expansions · score 0.05
- spinocerebellar ataxia type 12 · score 0.05
- parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development · score 0.04
- microcephaly, cataracts, impaired intellectual development, and dystonia with abnormal striatum · score 0.04
- Hereditary late-onset Parkinson disease · score 0.04
- atypical pantothenate kinase-associated neurodegeneration · score 0.04
- X-linked spinocerebellar ataxia type 4 · score 0.04
- Brunner syndrome · score 0.04
- neuroferritinopathy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NL88-F1 | alphafold | PREDICTED | 53.95 | — |
Amino-acid sequence (538 residues)
MPALLLLVLL ASSAGQARAR PSNATSAEPA GPLPALLAHL RRLTGALTGG GGAASPGANG TRTGPAGGAG AAARAPPPAE LCHGYYDVMG QYDATFNCST GSYRFCCGTC HYRFCCEHRH MRLAQASCSN YDTPRWATTP PPLAGGAGGA GGAGGGPGPG QAGWLEGGRT GGAGGRGGEG PGGSTAYVVC GVISFALAVG VGAKVAFSKA SRAPRAHRDI NVPRALVDIL RHQAGPGTRP DRARSSSLTP GIGGPDSMPP RTPKNLYNTV KTPNLDWRAL PPPSPSLHYS TLSCSRSFHN LSHLPPSYEA AVKSELNRYS SLKRLAEKDL DEAYLKRRPL ELPRGTLPLH ALRRPGTGGG YRMEAWGGPE ELGLAPAPNP RRVMSQEHLL GDGGRSRYEF TLPRARLVSQ EHLLLSSPEA LRQSREHLLS PPRSPALPPD PTARASLAAS HSNLLLGPGG PPTPLRGLPP PSSLHAHHHH ALHGSPQPAW MSDAGGGGGT LARRPPFQRQ GTLEQLQFIP GHHLPQHLRT ASKNEVTV
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