V-set and transmembrane domain-containing protein…

About V-set and transmembrane domain-containing protein 2B

V-set and transmembrane domain-containing protein 2B (VSTM2B) is a protein from Homo sapiens identified by UniProt accession A6NLU5, 285 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	V-set and transmembrane domain-containing protein 2B
UniProt accession	A6NLU5
Gene	VSTM2B
Organism	Homo sapiens
Length	285 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

protein measurement · score 0.31
heart rate response to exercise · score 0.05
metabolite measurement · score 0.04
coronary artery disease · score 0.01
neoplasm · score 0.00
Ataxia-telangiectasia · score 0.00
Delirium · score 0.00
breast cancer · score 0.00
female infertility · score 0.00
breast carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NLU5-F1	alphafold	PREDICTED	67.14	—

Amino-acid sequence (285 residues)

MEQRNRLGAL GYLPPLLLHA LLLFVADAAF TEVPKDVTVR EGDDIEMPCA FRASGATSYS LEIQWWYLKE PPRELLHELA LSVPGARSKV TNKDATKIST VRVQGNDISH RLRLSAVRLQ DEGVYECRVS DYSDDDTQEH KAQAMLRVLS RFAPPNMQAA EAVSHIQSSG PRRHGPASAA NANNAGAASR TTSEPGRGDK SPPPGSPPAA IDPAVPEAAA ASAAHTPTTT VAAAAAASSA SPPSGQAVLL RQRHGSGTGR SYTTDPLLSL LLLALHKFLR LLLGH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

V-set and transmembrane domain-containing protein 2B (VSTM2B)