About Zinc finger protein 729
Zinc finger protein 729 (ZNF729) is a protein
from Homo sapiens identified by UniProt accession
A6NN14, 1252 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | Zinc finger protein 729 |
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| UniProt accession | A6NN14 |
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| Gene | ZNF729 |
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| Organism | Homo sapiens |
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| Length | 1252 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (54)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- age at menopause · score 0.21
- smoking status measurement · score 0.21
- triglyceride measurement · score 0.21
- sitting height measurement · score 0.09
- age-related macular degeneration · score 0.07
- X-linked retinal dysplasia · score 0.06
- Familial exudative vitreoretinopathy · score 0.06
- retinitis pigmentosa · score 0.06
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NN14-F1 | alphafold | PREDICTED | 69.48 | — |
Amino-acid sequence (1252 residues)
MPGAPGSLEM GPLTFRDVTI EFSLEEWQCL DTVQQNLYRD VMLENYRNLV FLGMAVFKPD LITCLKQGKE PWNMKRHEMV TKPPVMRSHF TQDLWPDQST KDSFQEVILR TYARCGHKNL RLRKDCKSAN EGKMHKEGYN KLNQCRTATQ RKIFQCNKHM KVFHKYSNRN KVRHTKKKTF KCIKCSKSFF MLSCLIRHKR IHIRQNIYKC EERGKAFKSF STLTKHKIIH TEDKPYKYKK CGNAFKFSST FTKHKRIHTG ETPFRCEECG KAFNQSSNLT DHKRIHTGEK TYKCEECGKA FKGSSNFNAH KVIHTAEKPY KCEDCGKTFN HFSALRKHKI IHTGKKPYKR EECGKAFSQS STLRKHEIIH TGEKPYKCEE CGKAFKWSSK LTVHKVVHTG EKPYKCEECG KAFSQFSTLK KHKIIHTGKK PYKCEECGKA FNSSSTLMKH KIIHTGEKPY KCEECGKAFR QSSHLTRHKA IHTGEKPYKC EECGKAFNHF SDLRRHKIIH TGKKPYKCEE CGKAFSQSST LRNHQIIHTG EKPYKCEECG KAFKWSSKLT VHKVIHTGEK PCKCEECGKA FKHFSALRKH KVIHTREKLY KCEECGKAFN NSSILAKHKI IHTGKKPYKC EECGKAFRQS SHLTRHKAIH TGEKPYKCEE CGKAFSHFSA LRRHKIIHTG KKPYKCEECG KAFSHFSALR RHKIIHTGEK PYKCEECGKA FKWSSKLTVH KVIHTAEKPC KCEECGKSFK HFSALRKHKV IHTREKLYKC EECVKAFNSF SALMKHKVIH TGEKPYKCEE CGKAFKWSSK LTVHKVIHTG EKPCKCEECG KAFKHFSALR KHKVIHTGKK PYKCEECGKA FSQSSSLRKH EIIHSGEKPY KCEECGKAFK WLSKLTVHKV IHTAEKPCKC EECGKAFKHF SALRKHKIIH TGKKPYKCEE CGKAFNDSST LMKHKIIHTG KKPYKCAECG KAFKQSSHLT RHKAIHTGEK PYKCEECGKD FNNSSTLKKH KLIHTREKLY KCEECVKAFN NFSALMKHKI IHTGEKPYKC EECGKAFKWS SKLTEHKVIH TGEKPCKCEE CDKAFKHFSA LRKHKVIHTG KKPYQCDECG KAFNNSSTLT KHKIIHTGEK PYKCEECGKA FSQSSILTKH KIIHSVEKPY KCEECGKAFN QSSHLTRHKT IHTGEKPYKC EECGKAFIQC SYLIRHKTIH TREKPTNVKK VPKLLSNPHT LLDKTIHTGE KPYKCEECAK AF
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