About Gap junction epsilon-1 protein
Gap junction epsilon-1 protein (GJE1) is a protein
from Homo sapiens identified by UniProt accession
A6NN92, 205 residues long.
MolForge cross-references it against 0 known binders and
243 disease associations.
Target properties
| Protein name | Gap junction epsilon-1 protein |
|---|
| UniProt accession | A6NN92 |
|---|
| Gene | GJE1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 205 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (243)
Diseases linked to this target (Open Targets).
- body mass index · score 0.19
- forced expiratory volume · score 0.12
- blood protein measurement · score 0.12
- microphthalmia · score 0.10
- appendicular lean mass · score 0.09
- FEV/FVC ratio · score 0.08
- nanophthalmia · score 0.08
- early-onset non-syndromic cataract · score 0.08
- vital capacity · score 0.08
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NN92-F1 | alphafold | PREDICTED | 84.08 | — |
Amino-acid sequence (205 residues)
MSLNYIKNFY EGCVKPPTVI GQFHTLFFGS IRIFFLGVLG FAVYGNEALH FICDPDKREV NLFCYNQFRP ITPQVSFSAL QLVIVLVPGA LFHLYAACKS INQECILQKP IYTIIYILSV LLRISLAAIA FWLQIYLFGF QVKSLYLCDA RSLGENMIIR CMVPEHFEKT IFLIAINTFT TITILLFVAE IFEIIFRRLY FPFRQ
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