About Zinc finger protein 726
Zinc finger protein 726 (ZNF726) is a protein
from Homo sapiens identified by UniProt accession
A6NNF4, 616 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Zinc finger protein 726 |
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| UniProt accession | A6NNF4 |
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| Gene | ZNF726 |
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| Organism | Homo sapiens |
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| Length | 616 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- Testicular Germ Cell Tumor · score 0.43
- insulin measurement · score 0.23
- blood protein measurement · score 0.05
- Shwachman-Diamond syndrome · score 0.03
- atypical hemolytic-uremic syndrome with C3 anomaly · score 0.03
- atypical hemolytic-uremic syndrome with MCP/CD46 anomaly · score 0.03
- atypical hemolytic-uremic syndrome with I factor anomaly · score 0.03
- atypical hemolytic-uremic syndrome with thrombomodulin anomaly · score 0.03
- Blackfan-Diamond anemia · score 0.03
- tubulointerstitial kidney disease, autosomal dominant, 2 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NNF4-F1 | alphafold | PREDICTED | 74.10 | — |
Amino-acid sequence (616 residues)
MGLLTFRDVA IEFSLEEWQC LDTAQKNLYR NVMLENYRNL AFLGIAVSKP DLIICLEKEK EPWNMKRDEM VDEPPGICPH FAQDIWPEQG VEDSFQKVIL RRFEKCGHEN LQLRKGCKSV DECKVHKEGY NGLNQCFTTT QGKASQCGKY LKVFYKFINL NRYKIRHTRK KPFKCKNCVK SFCMFSHKTQ HKSIYTTEKS YKCKECGKTF NWSSTLTNHK KTHTEEKPYK CEEYGKAFNQ SSNYTTHKVT HTGEKPYKCE ECGKAFSQSS TLTIHKRIHT GEKPCKCEEC GKAFSQPSAL TIHKRMHIGE KPYKCEECGK AFVWSSTLTR HKRLHSGEKP YKCEECAKAF SQFGHLTTHR IIHTGEKPYK CEECGKAFIW PSTLTKHKRI HTGEKPYKCE ECGKAFHRSS NLTKHKIIHT GEKPYKCEEC GKAFIWSSNL TEHKKIHTRE KPYKCEECSK AFSRSSALTT HKRMHTGEKP YKCEECGKAF SQSSTLTAHK IIHTGEKPYK CEECGKAFIL SSTLSKHKRI HTGEKPYKCE ECGKTFNQSS NLSTHKIIHT GEKPYKCEEC GKAFNRSSNL STHKIIHTGE KPYKCDECGK SFIWSSTLFK HKRIHT
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