Dehydrogenase/reductase SDR family member 7C (DHRS7C)

About Dehydrogenase/reductase SDR family member 7C

Dehydrogenase/reductase SDR family member 7C (DHRS7C) is a protein from Homo sapiens identified by UniProt accession A6NNS2, 312 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Dehydrogenase/reductase SDR family member 7C
UniProt accession	A6NNS2
Gene	DHRS7C
Organism	Homo sapiens
Length	312 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

venous thromboembolism · score 0.09
metabolite measurement · score 0.04
colorectal cancer · score 0.04
allergic rhinitis · score 0.01
acute quadriplegic myopathy · score 0.01
colorectal adenocarcinoma · score 0.01
oral squamous cell carcinoma · score 0.01
Duchenne muscular dystrophy · score 0.00
autosomal dominant Emery-Dreifuss muscular dystrophy · score 0.00
pulmonary hypertension · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NNS2-F1	alphafold	PREDICTED	87.54	—

Amino-acid sequence (312 residues)

MGVMAMLMLP LLLLGISGLL FIYQEVSRLW SKSAVQNKVV VITDAISGLG KECARVFHTG GARLVLCGKN WERLENLYDA LISVADPSKQ TFTPKLVLLD LSDISCVPDV AKEVLDCYGC VDILINNASV KVKGPAHKIS LELDKKIMDA NYFGPITLTK ALLPNMISRR TGQIVLVNNI QGKFGIPFRT TYAASKHAAL GFFDCLRAEV EEYDVVISTV SPTFIRSYHV YPEQGNWEAS IWKFFFRKLT YGVHPVEVAE EVMRTVRRKK QEVFMANPIP KAAVYVRTFF PEFFFAVVAC GVKEKLNVPE EG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards