Tubulin beta 8B (TUBB8B)

About Tubulin beta 8B

Tubulin beta 8B (TUBB8B) is a protein from Homo sapiens identified by UniProt accession A6NNZ2, 444 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	Tubulin beta 8B
UniProt accession	A6NNZ2
Gene	TUBB8B
Organism	Homo sapiens
Length	444 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

viral disease · score 0.46
high density lipoprotein cholesterol measurement · score 0.26
non-small cell lung carcinoma · score 0.09
colorectal cancer · score 0.07
neuroblastoma · score 0.07
breast cancer · score 0.07
renal cell carcinoma · score 0.07
acute lymphoblastic leukemia · score 0.04
lymphoid neoplasm · score 0.04
childhood acute lymphoblastic leukemia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NNZ2-F1	alphafold	PREDICTED	91.36	—

Amino-acid sequence (444 residues)

MREIVLTQTG QCGNQIGAKF WEVISDEHAI DSAGTYHGDS HLQLERINVH HHEASGGRYV PRAVLVDLEP GTMDSVHSGP FGQVFRPDNF ISGQCGAGNN WAKGRYTEGA ELTESVMDVV RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIINTFSIL PSPKVSDTVV EPYNATLSVH QLIENADETF CIDNEALYDI CSRTLKLPTP TYGDLNHLVS ATMSGVTTCL RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVAELT QQMFDAKNMM AACDPRHGCY LTVAAIFRGR MPMREVDEQM FNIQDKNSSY FADWFPDNVK TAVCDIPPRG LKMSATFIGN NAAIQELFTC VSEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS EYQQYQDATA EEEEDEEYAE EEVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards