About Ankyrin repeat- and BTB/POZ domain-containing protein 3
Ankyrin repeat- and BTB/POZ domain-containing protein 3 (ABTB3) is a protein
from Homo sapiens identified by UniProt accession
A6QL63, 1104 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Ankyrin repeat- and BTB/POZ domain-containing protein 3 |
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| UniProt accession | A6QL63 |
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| Gene | ABTB3 |
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| Organism | Homo sapiens |
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| Length | 1104 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- body mass index · score 0.40
- platelet count · score 0.32
- oropharynx cancer · score 0.19
- human papilloma virus infection · score 0.19
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- body fat percentage · score 0.10
- blood protein measurement · score 0.09
- renal cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6QL63-F1 | alphafold | PREDICTED | 71.93 | — |
Amino-acid sequence (1104 residues)
MARRGKKPVV RTLEDLTLDS GYGGAADSVR SSNLSLCCSD SHPASPYGGS CWPPLADSMH SRHNSFDTVN TALVEDSEGL DCAGQHCSRL LPDLDEVPWT LQELEALLLR SRDPRAGPAV PGGLPKDALA KLSTLVSRAL VRIAKEAQRL SLRFAKCTKY EIQSAMEIVL SWGLAAHCTA AALAALSLYN MSSAGGDRLG RGKSARCGLT FSVGRVYRWM VDSRVALRIH EHAAIYLTAC MESLFRDIYS RVVASGVPRS CSGPGSGSGS GPGPSSGPGA APAADKEREA PGGGAASGGA CSAASSASGG SSCCAPPAAA AAAVPPAAAA NHHHHHHHAL HEAPKFTVET LEHTVNNDSE IWGLLQPYQH LICGKNASGV LCLPDSLNLH RDPQRSNKPG ELPMFSQSEL RTIEQSLLAT RVGSIAELSD LVSRAMHHLQ PLNAKHHGNG TPLHHKQGAL YWEPEALYTL CYFMHCPQME WENPNVEPSK VNLQVERPFL VLPPLMEWIR VAVAHAGHRR SFSMDSDDVR QAARLLLPGV DCEPRQLRAD DCFCASRKLD AVAIEAKFKQ DLGFRMLNCG RTDLVKQAVS LLGPDGINTM SEQGMTPLMY ACVRGDEAMV QMLLDAGADL NVEVVSTPHK YPSVHPETRH WTALTFAVLH GHIPVVQLLL DAGAKVEGSV EHGEENYSET PLQLAAAVGN FELVSLLLER GADPLIGTMY RNGISTTPQG DMNSFSQAAA HGHRNVFRKL LAQPEKEKSD ILSLEEILAE GTDLAETAPP PLCASRNSKA KLRALREAMY HSAEHGYVDV TIDIRSIGVP WTLHTWLESL RIAFQQHRRP LIQCLLKEFK TIQEEEYTEE LVTQGLPLMF EILKASKNEV ISQQLCVIFT HCYGPYPIPK LTEIKRKQTS RLDPHFLNNK EMSDVTFLVE GRPFYAHKVL LFTASPRFKA LLSSKPTNDG TCIEIGYVKY SIFQLVMQYL YYGGPESLLI KNNEIMELLS AAKFFQLEAL QRHCEIICAK SINTDNCVDI YNHAKFLGVT ELSAYCEGYF LKNMMVLIEN EAFKQLLYDK NGEGTGQDVL QDLQRTLAIR IQSIHLSSSK GSVV
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