Ankyrin repeat domain-containing protein 36A (ANKRD36)

About Ankyrin repeat domain-containing protein 36A

Ankyrin repeat domain-containing protein 36A (ANKRD36) is a protein from Homo sapiens identified by UniProt accession A6QL64, 1915 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Ankyrin repeat domain-containing protein 36A
UniProt accession	A6QL64
Gene	ANKRD36
Organism	Homo sapiens
Length	1915 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

deafness · score 0.32
hearing loss, autosomal recessive · score 0.32
cortical surface area measurement · score 0.32
brain measurement · score 0.29
alcohol consumption measurement · score 0.25
cortical thickness · score 0.23
response to lithium ion · score 0.10
bipolar disorder · score 0.10
schizophrenia · score 0.10
serum non-albumin protein measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6QL64-F1	alphafold	PREDICTED	49.68	—

Amino-acid sequence (1915 residues)

MEDGKRERWP TLMERLCSDG FAFPQYPIKP YHLKRIHRAV LHGNLEKLKY LLLTYYDANK RDRKERTALH LACATGQPEM VHLLVSRRCE LNLCDREDRT PLIKAVQLRQ EACATLLLQN GANPNITDFF GRTALHYAVY NEDTSMIEKL LSHGTNIEEC SKCEYQPLLF AVSRRKVKMV EFLLKKKANV NAIDYLGRSA LIHAVTLGEK DIVILLLQHN IDVLSRDAFR KIAGDYAIEA KNRVIFDLIY EYERKRYEDL PINSNPVSSQ KQPALKATSG KEDSISNIAT EIKDGQKSGT VSSQKQPALK DTSDKDDSVS NTATEIKDEQ KSGTVLPAVE QCLNRSLYRP DAVAQPVTEN EFSLESEIIS KLYIPKRKII SPRSIKDVLP PVEEAVDRCL YLLDRFAQPV TKDKFALESE NISEPYFTNR RTISQQSAEN LDAACGIDKT ENGNMFEDQN VDKEGKALPA TGQKANVSPE QPPLFTHTVK DRDHISTRFL GGMDSLTSSE ESSERPPLST LTLKEADPSS KAAMRRKDSP PPGKVSSQKQ PAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT SDEKDSVSNI ATEIKKGQQS GTVSPQKQSA WKVIFKKKVS LLNIATRIMG GGKSGTVSSQ KQPASKATSD KTDSALNIAT EIKDGLQCGT VSSQKQPALK ATTDEEDSVS NIATEIKDGE KSGTVSSQKQ PALKATTDEE DSVSNIATEI KDGEKSGTVS SQKQPALKAT TDEKDSVSNI ATEIKDGEKS GTVSSQKPPA LTATSDEEGS VLSIARENKD GEKSRTVSSR KKPALKATSD EKDSFSNITR GKKDGEISRK VSSQKPPTLK GTSDEEDSVL GIARENKDGE KSRTVSSEKP PGLKASSAEK DSVLNIARGK KDGEKTKRVS SRKKPSLEAT SDEKDSFSNI TREKKDGEIS RKVSSQKPPA LKGTSDEEDS VLGIARENKD GEKSRTVSSE KPPGLKATSD EKDSVLNIAR GKKDGEKTRT VSSQKPPTLK ATSDEEDSVL SIARENKDGE KSRTVSSEKP SGLKATSAEK DSVLNIARGK KYGEKTKRVS SRKKPALKAT SDEKDSVLYI AREKKDGEKS RTVSSPKQPA LKAICDKEDS VPNMATEKKD EQISGTVSCQ KQPALKATSD KKDSVSNIPT EIKDGQQSGT VSSQKQPAWK ATSVKKDSVS NIATEIKDGQ IRGTVSPQKQ SAQKVIFKKK VSLLNIATRI TGGWKSGTEY PENLPTLKAT IENKNSVLNT ATKMKDVQTS TPAEQDLEMA SEGEQKRLEE YENNQPQVKN QIHSRDDLDD IIQSSQTVSE DGDSLCCNCK NVILLIDQHE MKCKDCVHLL KIKNTFCLWK RLIKLKDNHC EQLRVKIRKL KNKASVLQKR ISEKEEIKSQ LKHEILELEK ELCSLRFAIQ QEKKKRRNVE EVHQKVREKL RITEEQYRIE ADVTKPIKPA LKSAEVELKT GGNNSNQVSE TDEKEDLLHE NRLMQDEIAR LRLEKDTIKN QNLEKKYLKD FEIVKRKHED LQKALKRNGE TLAKTIACYS GQLAALTDEN TTLRSKLEKQ RESRQRLETE MQSYHCRLNA ARCDHDQSHS SKRDQELAFQ GTVDKCRHLQ ENLNSHVLIL SLQLSKAESK SRVLKTELHY TGEALKEKAL VFEHVQSELK QKQSQMKDIE KMYKSGYNTM EKCIEKQERF CQLKKQNMLL QQQLDDARNK ADNQEKAILN IQARCDARVQ NLQAECRKHR LLLEEDNKML VNELNHSKEK ECQYEKEKAE REVAVRQLQQ KRDDVLNKGS ATKALLDASS RHCTYLENGM QDSRKKLDQM RSQFQEIQDQ LTATIRCTKE MEGDTQKLEV EHVMMRKIIK KQDDQIERLE KILQHSSLML QVFES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards