About Golgin subfamily A member 8A
Golgin subfamily A member 8A (GOLGA8A) is a protein
from Homo sapiens identified by UniProt accession
A7E2F4, 631 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Golgin subfamily A member 8A |
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| UniProt accession | A7E2F4 |
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| Gene | GOLGA8A |
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| Organism | Homo sapiens |
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| Length | 631 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.21
- refractive error · score 0.04
- colorectal adenocarcinoma · score 0.04
- pancreatic adenocarcinoma · score 0.04
- carcinoma of liver and intrahepatic biliary tract · score 0.03
- bacteriemia · score 0.02
- self reported educational attainment · score 0.02
- Pick disease · score 0.02
- breast carcinoma · score 0.01
- Abnormal sperm morphology · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A7E2F4-F1 | alphafold | PREDICTED | 66.22 | — |
Amino-acid sequence (631 residues)
MLPVDGEERK SEGSDTEGDR TSPCAVSSAT LKDLEVGGSG RRCSDPAGQP SNLLPQRGLG APLPAETAHT QPSPNDRSLY LSPKSSSASS SLHARQSPCQ EQAAVLNSRS IKISRLNDTI KSLKQQKKQV EHQLEEEKKA NNEKQKAERE LEGQIQRLNT EKKKLNTDLY HMKHSLRYFE EESKDLAGRL QRSSQRIGEL EWSLCAVAAT QKKKPDGFSS RSKALLKRQL EQSIREQILL KGHVTQLKES LKEVQLERDQ YAEQIKGERA QWQQRMRKMS QEVCTLKEEK KHDTHRVEEL ERSLSRLKNQ MAEPLPPDAP AVSSEVELQD LRKELERVAG ELQAQVENNQ CISLLNRGQK ERLREQEERL QEQQERLRER EKRLQQLAEP QSDLEELKHE NKSALQLEQQ VKELQEKLGQ VMETLTSAEK EPEAAVPASG TGGESSGLMD LLEEKADLRE HVEKLELGFI QYRRERCHQK VHRLLTEPGD SAKDASPGGG HHQAGPGQGG EEGEAAGAAG DGVAACGSYS EGHGKFLAAA RNPAAEPSPG APAPQELGAA DKHGDLCEAS LTNSVEPAQG EAREGSSQDN PTAQPVVQLL GEMQDHQEHP GLGSNCCVPC FCWAWLPRRR R
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