About Protein dispatched homolog 2
Protein dispatched homolog 2 (DISP2) is a protein
from Homo sapiens identified by UniProt accession
A7MBM2, 1401 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Protein dispatched homolog 2 |
|---|
| UniProt accession | A7MBM2 |
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| Gene | DISP2 |
|---|
| Organism | Homo sapiens |
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| Length | 1401 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.31
- intelligence · score 0.29
- self reported educational attainment · score 0.28
- cognitive function measurement · score 0.27
- BMI-adjusted waist circumference · score 0.27
- verbal-numerical reasoning measurement · score 0.22
- vital capacity · score 0.22
- diverticular disease · score 0.20
- asthma · score 0.20
- diverticulitis · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A7MBM2-F1 | alphafold | PREDICTED | 67.54 | — |
Amino-acid sequence (1401 residues)
MDGDSSSSSG GSGPAPGPGP EGEQRPEGEP LAPDGGSPDS TQTKAVPPEA SPERSCSLHS CPLEDPSSSS GPPPTTSTLQ PVGPSSPLAP AHFTYPRALQ EYQGGSSLPG LGDRAALCSH GSSLSPSPAP SQRDGTWKPP AVQHHVVSVR QERAFQMPKS YSQLIAEWPV AVLMLCLAVI FLCTLAGLLG ARLPDFSKPL LGFEPRDTDI GSKLVVWRAL QALTGPRKLL FLSPDLELNS SSSHNTLRPA PRGSAQESAV RPRRMVEPLE DRRQENFFCG PPEKSYAKLV FMSTSSGSLW NLHAIHSMCR MEQDQIRSHT SFGALCQRTA ANQCCPSWSL GNYLAVLSNR SSCLDTTQAD AARTLALLRT CALYYHSGAL VPSCLGPGQN KSPRCAQVPT KCSQSSAIYQ LLHFLLDRDF LSPQTTDYQV PSLKYSLLFL PTPKGASLMD IYLDRLATPW GLADNYTSVT GMDLGLKQEL LRHFLVQDTV YPLLALVAIF FGMALYLRSL FLTLMVLLGV LGSLLVAFFL YQVAFRMAYF PFVNLAALLL LSSVCANHTL IFFDLWRLSK SQLPSGGLAQ RVGRTMHHFG YLLLVSGLTT SAAFYASYLS RLPAVRCLAL FMGTAVLVHL ALTLVWLPAS AVLHERYLAR GCARRARGRW EGSAPRRLLL ALHRRLRGLR RAAAGTSRLL FQRLLPCGVI KFRYIWICWF AALAAGGAYI AGVSPRLRLP TLPPPGGQVF RPSHPFERFD AEYRQLFLFE QLPQGEGGHM PVVLVWGVLP VDTGDPLDPR SNSSLVRDPA FSASGPEAQR WLLALCHRAR NQSFFDTLQE GWPTLCFVET LQRWMESPSC ARLGPDLCCG HSDFPWAPQF FLHCLKMMAL EQGPDGTQDL GLRFDAHGSL AALVLQFQTN FRNSPDYNQT QLFYNEVSHW LAAELGMAPP GLRRGWFTSR LELYSLQHSL STEPAVVLGL ALALAFATLL LGTWNVPLSL FSVAAVAGTV LLTVGLLVLL EWQLNTAEAL FLSASVGLSV DFTVNYCISY HLCPHPDRLS RVAFSLRQTS CATAVGAAAL FAAGVLMLPA TVLLYRKLGI ILMMVKCVSC GFASFFFQSL CCFFGPEKNC GQILWPCAHL PWDAGTGDPG GEKAGRPRPG SVGGMPGSCS EQYELQPLAR RRSPSFDTST ATSKLSHRPS VLSEDLQLHD GPCCSRPPPA PASPRELLLD HQAVFSQCPA LQTSSPYKQA GPSPKTRARQ DSQGEEAEPL PASPEAPAHS PKAKAADPPD GFCSSASTLE GLSVSDETCL STSEPSARVP DSVGVSPDDL DDTGQPVLER GQLNGKRDTL WLALRETVYD PSLPASHHSS LSWKGRGGPG DGSPVVLPNS QPDLPDVWLR RPSTHTSGYS S
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