About TANK-binding kinase 1-binding protein 1
TANK-binding kinase 1-binding protein 1 (TBKBP1) is a protein
from Homo sapiens identified by UniProt accession
A7MCY6, 615 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | TANK-binding kinase 1-binding protein 1 |
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| UniProt accession | A7MCY6 |
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| Gene | TBKBP1 |
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| Organism | Homo sapiens |
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| Length | 615 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (57)
Diseases linked to this target (Open Targets).
- body mass index · score 0.32
- physical activity measurement · score 0.30
- blood phosphate measurement · score 0.23
- apolipoprotein B measurement · score 0.20
- blood protein measurement · score 0.20
- total blood protein measurement · score 0.19
- sex hormone-binding globulin measurement · score 0.16
- serum non-albumin protein measurement · score 0.15
- hematocrit · score 0.15
- HbA1c measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A7MCY6-F1 | alphafold | PREDICTED | 63.40 | — |
Amino-acid sequence (615 residues)
MESMFEDDIS ILTQEALGPS EVWLDSPGDP SLGGDMCSAS HFALITAYGD IKERLGGLER ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKDGSLLE VEKVSLQQRL NQFQHELQKN KEQEEQLGEM IQAYEKLCVE KSDLETELRE MRALVETHLR QICGLEQQLR QQQGLQDAAF SNLSPPPAPA PPCTDLDLHY LALRGGSGLS HAGWPGSTPS VSDLERRRLE EALEAAQGEA RGAQLREEQL QAECERLQGE LKQLQETRAQ DLASNQSERD MAWVKRVGDD QVNLALAYTE LTEELGRLRE LSSLQGRILR TLLQEQARSG GQRHSPLSQR HSPAPQCPSP SPPARAAPPC PPCQSPVPQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS PVPPSCQSPS PQRRSPVPPS CPAPQPRPPP PPPPGERTLA ERAYAKPPSH HVKAGFQGRR SYSELAEGAA YAGASPPWLQ AEAATLPKPR AYGSELYGPG RPLSPRRAFE GIRLRFEKQP SEEDEWAVPT SPPSPEVGTI RCASFCAGFP IPESPAATAY AHAEHAQSWP SINLLMETVG SDIRSCPLCQ LGFPVGYPDD ALIKHIDSHL ENSKI
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