About POU class 2 homeobox associating factor 3
POU class 2 homeobox associating factor 3 (POU2AF3) is a protein
from Homo sapiens identified by UniProt accession
A8K830, 251 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | POU class 2 homeobox associating factor 3 |
|---|
| UniProt accession | A8K830 |
|---|
| Gene | POU2AF3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 251 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (58)
Diseases linked to this target (Open Targets).
- colorectal cancer · score 0.47
- rectum cancer · score 0.31
- blood protein measurement · score 0.30
- polyp of colon · score 0.30
- colorectal adenoma · score 0.30
- polyp of rectum · score 0.27
- hemoglobin measurement · score 0.27
- erythrocyte count · score 0.24
- creatinine measurement · score 0.23
- benign colon neoplasm · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8K830-F1 | alphafold | PREDICTED | 55.47 | — |
Amino-acid sequence (251 residues)
MSEKPKVYQG VRVKITVKEL LQQRRAHQAA SGGTRSGGSS VHLSDPVAPS SAGLYFEPEP ISSTPNYLQR GEFSSCVSCE ENSSCLDQIF DSYLQTEMHP EPLLNSTQSA PHHFPDSFQA TPFCFNQSLI PGSPSNSSIL SGSLDYSYSP VQLPSYAPEN YNSPASLDTR TCGYPPEDHS YQHLSSHAQY SCFSSATTSI CYCASCEAED LDALQAAEYF YPSTDCVDFA PSAAATSDFY KRETNCDICY S
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