About EF-hand calcium-binding domain-containing protein 7
EF-hand calcium-binding domain-containing protein 7 (EFCAB7) is a protein
from Homo sapiens identified by UniProt accession
A8K855, 629 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | EF-hand calcium-binding domain-containing protein 7 |
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| UniProt accession | A8K855 |
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| Gene | EFCAB7 |
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| Organism | Homo sapiens |
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| Length | 629 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (17)
Diseases linked to this target (Open Targets).
- mean reticulocyte volume · score 0.23
- mean corpuscular volume · score 0.21
- mean corpuscular hemoglobin · score 0.18
- postaxial polydactyly · score 0.15
- eye color · score 0.12
- deafness · score 0.05
- congenital enteropathy due to enteropeptidase deficiency · score 0.03
- gastric mucosal hypertrophy · score 0.03
- acute quadriplegic myopathy · score 0.03
- appendicular lean mass · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8K855-F1 | alphafold | PREDICTED | 80.26 | — |
Amino-acid sequence (629 residues)
MAISPRSDAT FSSQKSTPSE SPRTKKFPLT EEEIFYMNCR AAYLTVFKSS LENIISKDQL YLALQHAGRN PSQKTINKYW TPQTAKLNFD DFCIILRKEK PTSKAELLKS FKQLDVNDDG CILHTDLYKF LTKRGEKMTR EEVNAIINLA DVNADGKFDY IKFCKLYMTT NEQCLKTTLE KLEVDSKLMR HQFGNHIEGS PERDPSPVPK PSPKITRKTD PETFLNKGDT RSSLLSATRK FKTSVSFTVT MGANGNRNSK LMEPNLIKDW QHMQSKGCFF LEEDGEIISH QYRMQIAQRS MVYLTIKPLN LSQVEGKPSP WLSVDTALYI LKENESQANL QLVCFTELRN REVFGWTGEL GPGIYWLIPS TTGCRLRKKI KPVTDEAQLV YRDETGELFL TKEFKSTLSD IFEVIDLDGN GLLSLEEYNF FELRTSGEKC DEDAWAVCRE NFDTKRNELT RQGFMDLNLM EANDREGDPC DLWVTLHSMG YNKALELTEA CPFVIDIYAE KCKPKIKAVH MEACSGQLEK AICKSVLSNG DAKVMDGYEN IIVHTYSCDT WITSVIENKS DEKVIIHISN ELSKNCINNR GLNIFAVEVG PKSTMVCQHV MPLNERQEWI YYCIYSLIS
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