About ERI1 exoribonuclease 2
ERI1 exoribonuclease 2 (ERI2) is a protein
from Homo sapiens identified by UniProt accession
A8K979, 691 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | ERI1 exoribonuclease 2 |
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| UniProt accession | A8K979 |
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| Gene | ERI2 |
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| Organism | Homo sapiens |
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| Length | 691 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (18)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.31
- eosinophil count · score 0.26
- systolic blood pressure · score 0.24
- urate measurement · score 0.20
- body height · score 0.17
- erythrocyte count · score 0.16
- eosinophil percentage of leukocytes · score 0.12
- sitting height measurement · score 0.08
- drug use measurement · score 0.05
- diastolic blood pressure · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8K979-F1 | alphafold | PREDICTED | 58.90 | — |
Amino-acid sequence (691 residues)
MATKRLARQL GLIRRKSIAP ANGNLGRSKS KQLFDYLIVI DFESTCWNDG KHHHSQEIIE FPAVLLNTST GQIDSEFQAY VQPQEHPILS EFCMELTGIK QAQVDEGVPL KICLSQFCKW IHKIQQQKNI IFATGISEPS ASEVKLCAFV TWSDWDLGVC LEYECKRKQL LKPVFLNSWI DLRATYKLFY RRKPKGLSGA LQEVGIEFSG REHSGLDDSR NTALLAWKMI RDGCVMKITR SLNKVPTKKN FSILARNLNT IQVEEMSACN ISIQGPSIYN KEPKNIINPH EKVQMKSICA NSPIKAQQDQ LQVKNNIKAS LHNVKSSLPL FNTKSSTSVG QLQSPTLNSP IYMQKQGKNE HLAFNTKSKA STVGSELVLV STTVPTVHHV SDLEMSSTLD CLPVLADWED VVLLPASQPE ENVDCTVPIS DSDLEISFNS GERLMVLKEL EMSSHENFGD IEETPQKSET SKSIVYKSPH TTIYNVKEAK DPGSDISAFK LPEHKSSTFN RVNANMSHPL VLGKHPLLSG GTKRNPCSPQ AFPPAKKQPF TIHEEKPTSS DCSPVRSSSW RRLPSILTST VNLQEPWKSG KMTPPLCKCG RRSKRLVVSN NGPNHGKVFY CCPIGKYQEN RKCCGYFKWE QTLQKERANS MVPSHSTGGL TFSSPETSHI CDRNLSISTK NSLRLRPSMR N
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