About E3 ubiquitin-protein ligase NEURL1B
E3 ubiquitin-protein ligase NEURL1B (NEURL1B) is a protein
from Homo sapiens identified by UniProt accession
A8MQ27, 555 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase NEURL1B |
|---|
| UniProt accession | A8MQ27 |
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| Gene | NEURL1B |
|---|
| Organism | Homo sapiens |
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| Length | 555 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.45
- lymphocyte count · score 0.43
- gut microbiome measurement · score 0.33
- protein measurement · score 0.33
- lymphocyte percentage of leukocytes · score 0.32
- vital capacity · score 0.30
- FEV/FVC ratio · score 0.28
- eosinophil count · score 0.16
- genetic disorder · score 0.15
- BMI-adjusted waist-hip ratio · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MQ27-F1 | alphafold | PREDICTED | 70.62 | — |
Amino-acid sequence (555 residues)
MGNTVHRTLP DPSPPARLLA TRPCCGPGPE RRPVLGEAPR FHAQAKGKNV RLDGHSRRAT RRNSFCNGVT FTQRPIRLYE QVRLRLVAVR PGWSGALRFG FTAHDPSLMS AQDIPKYACP DLVTRPGYWA KALPENLALR DTVLAYWADR HGRVFYSVND GEPVLFHCGV AVGGPLWALI DVYGITDEVQ LLESAFADTL TPARLSQARF SACLPPSSHD AANFDNNELE NNQVVAKLGH LALGRAPGPP PADAAAAAIP CGPRERPRPA SSPALLEADL RFHATRGPDV SLSADRKVAC APRPDGGRTL VFSERPLRPG ESLFVEVGRP GLAAPGALAF GITSCDPGVL RPNELPADPD ALLDRKEYWV VARAGPVPSG GDALSFTLRP GGDVLLGING RPRGRLLCVD TTQALWAFFA VRGGVAGQLR LLGTLQSSPA TTTPSGSLSG SQDDSDSDMT FSVNQSSSAS ESSLVTAPSS PLSPPVSPVF SPPEPAGIKN GECTVCFDGE VDTVIYTCGH MCLCHSCGLR LKRQARACCP ICRRPIKDVI KIYRP
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