About Golgin subfamily A member 8B
Golgin subfamily A member 8B (GOLGA8B) is a protein
from Homo sapiens identified by UniProt accession
A8MQT2, 603 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Golgin subfamily A member 8B |
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| UniProt accession | A8MQT2 |
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| Gene | GOLGA8B |
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| Organism | Homo sapiens |
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| Length | 603 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (15)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- refractive error · score 0.30
- Myopia · score 0.04
- axial length measurement · score 0.04
- Hypermetropia · score 0.04
- colorectal adenocarcinoma · score 0.04
- Abnormality of refraction · score 0.04
- refractive error measurement · score 0.04
- age at onset · score 0.04
- self reported educational attainment · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MQT2-F1 | alphafold | PREDICTED | 68.49 | — |
Amino-acid sequence (603 residues)
MAEETGQSKL AAAKKKFKEY WQRNRPGVPA AAKRNTKANG SSPETAASGG CHSSEASSSA SSSLHARQSP CQEQAAVLNS RSIKISRLND TIKSLKQQKK QVEHQLEEEK KANNEKQKAE RELEGQIQRL NTEKKKLNTD LYHMKHSLRY FEEESKDLAG RLQRSSQRIG ELEWSLCAVA ATQKKKPDGF SSRSKALLKR QLEQSIREQI LLKGHVTQLK ESLKEVQLER DQYAEQIKGE RAQWQQRMRK MSQEVCTLKE EKKHDTHRVE ELERSLSRLK NQMAEPLPPD APAVSSEVEL QDLRKELERV AGELQAQVEN NQCISLLNRG QKERLREQEE RLQEQQERLR EREKRLQQLA EPQSDLEELK HENKSALQLE QQVKELQEKL GQVMETLTSA EKEPEAAVPA SGTGGESSGL MDLLEEKADL REHVEKLELG FIQYRRERCH QKVHRLLTEP GDSAKDASPG GGHHQAGPGQ GGEEGEAAGA AGDGVAACGS YSEGHGKFLA AARNPAAEPS PGAPAPQELG AADKHGDLCE ASLTNSVEPA QGEAREGSSQ DNPTAQPVLQ LLGEMQDHQE HPGLGSNCCV PCFCWAWLPR RRR
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