Centromere protein X (CENPX)

About Centromere protein X

Centromere protein X (CENPX) is a protein from Homo sapiens identified by UniProt accession A8MT69, 81 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.

Target properties

Protein name	Centromere protein X
UniProt accession	A8MT69
Gene	CENPX
Organism	Homo sapiens
Length	81 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (37)

Diseases linked to this target (Open Targets).

BMI-adjusted hip circumference · score 0.18
body height · score 0.17
BMI-adjusted waist-hip ratio · score 0.15
FEV/FVC ratio · score 0.11
vital capacity · score 0.10
type 2 diabetes mellitus · score 0.07
heel bone mineral density · score 0.06
forced expiratory volume · score 0.05
birth weight · score 0.05
parental genotype effect measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A8MT69-F1	alphafold	PREDICTED	92.57	—

Amino-acid sequence (81 residues)

MEGAGAGSGF RKELVSRLLH LHFKDDKTKV SGDALQLMVE LLKVFVVEAA VRGVRQAQAE DALRVDVDQL EKVLPQLLLD F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards