Ciliary microtubule inner protein 2B (CIMIP2B)

About Ciliary microtubule inner protein 2B

Ciliary microtubule inner protein 2B (CIMIP2B) is a protein from Homo sapiens identified by UniProt accession A8MTA8, 275 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Ciliary microtubule inner protein 2B
UniProt accession	A8MTA8
Gene	CIMIP2B
Organism	Homo sapiens
Length	275 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

protein measurement · score 0.20
Meckel syndrome · score 0.11
chronic myeloproliferative disorder · score 0.04
linear and whorled nevoid hypermelanosis · score 0.04
eosinophil peroxidase deficiency · score 0.04
neutropenia, severe congenital, 1, autosomal dominant · score 0.04
ichthyosis prematurity syndrome · score 0.03
chronic myelogenous leukemia · score 0.03
neoplasm · score 0.01
non-small cell lung carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A8MTA8-F1	alphafold	PREDICTED	68.78	—

Amino-acid sequence (275 residues)

MAVASTFIPG LNPQNPHYIP GYTGHCPLLR FSVGQTYGQV TGQLLRGPPG LAWPPVHRTL LPPIRPPRSP EVPRESLPVR RGQERLSSSM IPGYTGFVPR AQFIFAKNCS QVWAEALSDF THLHEKQGSE ELPKEAKGRK DTEKDQVPEP EGQLEEPTLE VVEQASPYSM DDRDPRKFFM SGFTGYVPCA RFLFGSSFPV LTNQALQEFG QKHSPGSAQD PKHLPPLPRT YPQNLGLLPN YGGYVPGYKF QFGHTFGHLT HDALGLSTFQ KQLLA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards