E3 ubiquitin-protein ligase RNF212B (RNF212B)

About E3 ubiquitin-protein ligase RNF212B

E3 ubiquitin-protein ligase RNF212B (RNF212B) is a protein from Homo sapiens identified by UniProt accession A8MTL3, 300 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNF212B
UniProt accession	A8MTL3
Gene	RNF212B
Organism	Homo sapiens
Length	300 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.41
platelet count · score 0.32
testosterone measurement · score 0.31
total blood protein measurement · score 0.27
mean platelet volume · score 0.27
female infertility · score 0.27
triglyceride measurement · score 0.26
bone density · score 0.17
urate measurement · score 0.17
platelet component distribution width · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A8MTL3-F1	alphafold	PREDICTED	66.29	—

Amino-acid sequence (300 residues)

MDWFHCNQCF RKDGAHFFVT SCGHIFCKKC VTLEKCAVCG TACKHLALSD NLKPQEKMFF KSPVETALQY FSHISQVWSF QKKQTDLLIA FYKHRITKLE TAMQEAQQAL VSQDKELSVL RKENGELKKF LAILKESPSR YQGSRSITPR PVGITSPSQS VTPRPSFQHS SQVVSRSSSA ESIPYREAGF GSLGQGGRGL QGRRTPRDSY NETPSPASTH SLSYRTSSAS SGQGIFSFRP SPNGHSGHTR VLTPNNFAQR ESTTTLESLP SFQLPVLQTL YQQRRHMGLP SGREAWTTSR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards