About Zinc finger protein 724
Zinc finger protein 724 (ZNF724) is a protein
from Homo sapiens identified by UniProt accession
A8MTY0, 619 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Zinc finger protein 724 |
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| UniProt accession | A8MTY0 |
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| Gene | ZNF724 |
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| Organism | Homo sapiens |
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| Length | 619 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (25)
Diseases linked to this target (Open Targets).
- X-linked severe congenital neutropenia · score 0.04
- Blackfan-Diamond anemia · score 0.04
- neutropenia, severe congenital, 2, autosomal dominant · score 0.04
- nonimmune chronic idiopathic neutropenia of adults · score 0.04
- autosomal recessive severe congenital neutropenia due to CSF3R deficiency · score 0.04
- reticular dysgenesis · score 0.04
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 · score 0.04
- combined immunodeficiency with skin granulomas · score 0.04
- combined immunodeficiency due to moesin deficiency · score 0.04
- X-linked sideroblastic anemia 1 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MTY0-F1 | alphafold | PREDICTED | 75.69 | — |
Amino-acid sequence (619 residues)
MGPLTFMDVA IEFSVEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSKP DLITCLEQGK EPWNMERHEM VAKPPGMCCY FAQDLRPEQS IKASLQRIIL RKYEKCGHHN LQLKKGYKSV DEYKVHKGSY NGFNQCLTTT QSKIFQCDKY VKDFHKFSNS NRHKTEKNPF KCKECGKSFC VLSHLTQHKR IHTTVNSYKL EECGKAFNVS STLSQHKRIH TGQKHYKCEE CGIAFNKSSH LNTHKIIHTG EKSYKREECG KAFNISSHLT THKIIHTGEN AYKCKECGKA FNQSSTLTRH KIIHAGEKPY ICEHCGRAFN QSSNLTKHKR IHTGDKPYKC EECGKAFNVS STLTQHKRIH TGEKPYKCEE CGKAFNVSST LTQHKRIHTG EKPYKCEECG KAFNTSSHLT THKRIHTGEK PYKCEECGKA FNQFSQLTTH KIIHTGEKPY KCKECGKAFK RSSNLTEHRI IHTGEKPYKC EECGKAFNLS SHLTTHKKIH TGEKPYKCKE CGKAFNQSST LARHKIIHAG EKPYKCEECG KAFYQYSNLT QHKIIHTGEK PYKCEECGKA FNWSSTLTKH KVIHTGEKPY KCKECGKAFN QCSNLTTHKK IHAVEKSDK
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