About Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial
Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial (CSKMT) is a protein
from Homo sapiens identified by UniProt accession
A8MUP2, 240 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial |
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| UniProt accession | A8MUP2 |
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| Gene | CSKMT |
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| Organism | Homo sapiens |
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| Length | 240 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin concentration · score 0.20
- resting heart rate · score 0.19
- body fat percentage · score 0.15
- blood protein measurement · score 0.15
- low density lipoprotein triglyceride measurement · score 0.10
- high density lipoprotein cholesterol measurement · score 0.10
- aspartate aminotransferase measurement · score 0.10
- serum alanine aminotransferase measurement · score 0.10
- sex hormone-binding globulin measurement · score 0.10
- triglyceride measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MUP2-F1 | alphafold | PREDICTED | 87.65 | — |
Amino-acid sequence (240 residues)
MAALRRMLHL PSLMMGTCRP FAGSLADSCL ADRCLWDRLH AQPRLGTVPT FDWFFGYDEV QGLLLPLLQE AQAASPLRVL DVGCGTSSLC TGLYTKSPHP VDVLGVDFSP VAVAHMNSLL EGGPGQTPLC PGHPASSLHF MHADAQNLGA VASSGSFQLL LDKGTWDAVA RGGLPRAYQL LSECLRVLNP QGTLIQFSDE DPDVRLPCLE QGSYGWTVTV QELGPFRGIT YFAYLIQGSH
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