Meiosis-specific protein MEI4 (MEI4)

About Meiosis-specific protein MEI4

Meiosis-specific protein MEI4 (MEI4) is a protein from Homo sapiens identified by UniProt accession A8MW99, 385 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	Meiosis-specific protein MEI4
UniProt accession	A8MW99
Gene	MEI4
Organism	Homo sapiens
Length	385 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

vertebral disorder · score 0.33
mathematical ability · score 0.31
adolescent idiopathic scoliosis · score 0.30
tissue factor measurement · score 0.13
azoospermia · score 0.08
male infertility with teratozoospermia due to single gene mutation · score 0.07
46,XX testicular disorder of sex development · score 0.06
partial chromosome Y deletion · score 0.06
Testicular regression syndrome · score 0.06
isolated congenital hypogonadotropic hypogonadism · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A8MW99-F1	alphafold	PREDICTED	70.21	—

Amino-acid sequence (385 residues)

MDVQKWYLRT SKLALALAII RSKPADKSSR EYTEHLAMLL SEEQSKWRSK VEILEAEVMQ LRQKLLVSRL CSGSFKSGYV SSQLEAQEPK SSESTLTSME DSGCDLSNEQ RTESSDLSQH FVESCTPTHF PPLPLVKRPC AILQNPLSSH MQFLQYLLEL KNLTESGNLK RDLTHFEKDS STVSDSVFQL LDGLITFYRN PKLPFSRFWT EAVGTLASLI SDYNLSSHIL KKCSKKLEEF EKTLLHAILG NNHINQFQVQ HYVSQSLVTL GNCSLLRKSI ISLLLSEVNG FADDLGAINQ EQASYDVSRY ENIFYLFWVL EQLLQKETEE GNTSSIGHDD QEIKKFLQKH DETIFQLSDA FPLFTFYLWR VGILLSSAQI ETLRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards