EF-hand calcium-binding domain-containing protein 8…

About EF-hand calcium-binding domain-containing protein 8

EF-hand calcium-binding domain-containing protein 8 (EFCAB8) is a protein from Homo sapiens identified by UniProt accession A8MWE9, 144 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	EF-hand calcium-binding domain-containing protein 8
UniProt accession	A8MWE9
Gene	EFCAB8
Organism	Homo sapiens
Length	144 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.32
diffuse plaque measurement · score 0.28
neurodegenerative disease · score 0.24
chronotype measurement · score 0.24
polycystic ovary syndrome · score 0.18
hair shape measurement · score 0.16
cup-to-disc ratio measurement · score 0.13
body height · score 0.12
hair colour measurement · score 0.11
Red cell distribution width · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A8MWE9-F1	alphafold	PREDICTED	68.96	—

Amino-acid sequence (144 residues)

MSSEDLAEIP QLQKLSIPHG FQNKEAASSP TPSITLSQVP DLQPGSQLFT EIHLAKIEKM FEEDINSTGA LGMDAFIKAM KKVLSSVSDE MLKELFLKVD SDCEGFVTWQ KYVDYMMREF QGKEDMRKSQ YRLHFYLPMT VVPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

EF-hand calcium-binding domain-containing protein 8 (EFCAB8)