V-set and transmembrane domain-containing protein 5…

About V-set and transmembrane domain-containing protein 5

V-set and transmembrane domain-containing protein 5 (VSTM5) is a protein from Homo sapiens identified by UniProt accession A8MXK1, 200 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	V-set and transmembrane domain-containing protein 5
UniProt accession	A8MXK1
Gene	VSTM5
Organism	Homo sapiens
Length	200 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

response to selective serotonin reuptake inhibitor · score 0.22
metabolite measurement · score 0.07
Barrett's esophagus · score 0.05
esophageal adenocarcinoma · score 0.03
autism · score 0.01
Colon Sessile Serrated Adenoma/Polyp · score 0.00
psychiatric disorder · score 0.00
autoimmune disease · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A8MXK1-F1	alphafold	PREDICTED	88.23	—

Amino-acid sequence (200 residues)

MRPLPSGRRK TRGISLGLFA LCLAAARCLQ SQGVSLYIPQ ATINATVKED ILLSVEYSCH GVPTIEWTYS SNWGTQKIVE WKPGTQANIS QSHKDRVCTF DNGSIQLFSV GVRDSGYYVI TVTERLGSSQ FGTIVLHVSE ILYEDLHFVA VILAFLAAVA AVLISLMWVC NKCAYKFQRK RRHKLKESTT EEIELEDVEC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

V-set and transmembrane domain-containing protein 5 (VSTM5)