About Zinc finger protein 99
Zinc finger protein 99 (ZNF99) is a protein
from Homo sapiens identified by UniProt accession
A8MXY4, 864 residues long.
MolForge cross-references it against 0 known binders and
11 disease associations.
Target properties
| Protein name | Zinc finger protein 99 |
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| UniProt accession | A8MXY4 |
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| Gene | ZNF99 |
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| Organism | Homo sapiens |
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| Length | 864 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (11)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.18
- adolescent idiopathic scoliosis · score 0.07
- upper extremity fracture · score 0.06
- Down syndrome · score 0.05
- neoplasm · score 0.01
- hepatocellular carcinoma · score 0.01
- non-small cell lung carcinoma · score 0.00
- breast angiosarcoma · score 0.00
- cancer · score 0.00
- multiple sclerosis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MXY4-F1 | alphafold | PREDICTED | 72.37 | — |
Amino-acid sequence (864 residues)
MGSLTFWDVT IEFALEEWQC LDMAQQNLYR NVMLENYRNL VFLGIAVSKL DLITCLKQGK EPWNMKRHEM VTKPPVISSH FTQDFWPDQS IKDSFQEIIL RTYARCGHKN LRLRKDCESV NEGKMHEEAY NKLNQCWTTT QGKIFQCNKY VKVFHKYSNS NRYKIRHTKK KTFKCMKCSK SFFMLSHLIQ HKRIHTRENI YKCEERGKAF KWFSTLIKHK IIHTEDKPYK YKKCGKAFNI SSMFTKCKII HTGKKPCKCE ECGKVFNNSS TLMKHKIIHT GKKPYKCEEC GKAFKQSSHL TRHKAIHTGE KPYKCEECGK AFNHFSALRK HQIIHTGKKP YKCEECGKAF SQSSTLRKHE IIHTEEKPYK YEECGKAFSN LSALRKHEII HTGQKPYKCE ECGKAFKWSS KLTVHKVIHT AEKPCKCEEC GKAFKRFSAL RKHKIIHTGK QPYKCEECSK AFSNFSALRK HEIIHTGEKP YKCEECGKAF KWSSKLTVHK VIHMEEKPCK CEECGKAFKH FSALRKHKII HTGKKPYKCE ECGKAFNNSS TLMKHKIIHT GKKPYKCEEC GKAFKQSSHL TRHKAIHTGE KPYKCEECGK AFNHFSALRK HQIIHTGKKP YKCEECGKAF SQSSTLRKHE IIHTGEKPYK CEECGKAFKW SSHLTRHKVI HTEEKPYKCE ECGKAFNHFS ALRKHKIIHT GKKPYKCEEC GKAFSQSSTL RKHEIIHTGE KPYKCEECGK AFKWSSKLTV HKVIHTAEKP CKCEECGKAF KHFSALRKHK IIHTGKKPYK CEECGKAFNN SSTLRKHEII HTGEKSYKCE ECGKAFQWSS KLTLHKVIHM ERNPANVKNV AKLLNISQPL ENMR
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