About Tetratricopeptide repeat protein 34
Tetratricopeptide repeat protein 34 (TTC34) is a protein
from Homo sapiens identified by UniProt accession
A8MYJ7, 566 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Tetratricopeptide repeat protein 34 |
|---|
| UniProt accession | A8MYJ7 |
|---|
| Gene | TTC34 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 566 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (42)
Diseases linked to this target (Open Targets).
- hair shape measurement · score 0.30
- brain measurement · score 0.30
- cortical thickness · score 0.30
- neuroimaging measurement · score 0.30
- cortical surface area measurement · score 0.30
- multiple sclerosis · score 0.28
- brain volume measurement · score 0.25
- upper face morphology measurement · score 0.25
- neurodegenerative disease · score 0.25
- cervical carcinoma · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MYJ7-F1 | alphafold | PREDICTED | 87.14 | — |
Amino-acid sequence (566 residues)
MLQRSPRAGP SRAQGRREAA ETGGPTTQEG VACGVHQLAT LLMELDSEDE ASRLLAADAL YRLGRLEETH KALLVALSRR PQAAPVLARL ALLQLRRGFF YDANQLVKKL VQSGDTACLQ PTLDVFCHED RQLLQGHCHA RALAILRARP GGADGRVHTK EAIAYLSLAI FAAGSQASES LLARARCYGF LGQKKTAMFD FNTVLRAEPG NVQALCGRAL VHLALDQLQE AVDDIVSALK LGPGTVVPEL RSLKPEAQAL ITQGLYSHCR ALLSQLPDTG APLEDKDTQG LLAVGEALIK IDSGQPHWHL LLADILMAQG SYEEAGTHLE KALHRAPTSE AARARLGLLQ LKKGDVPGAA RDLQSLAEVD APDLSCLLHL LEASERQSLA QAAAQEAGTL LDAGQPRQAL GYCSLSVLAS GSSACHLRLR ATCLAELQEF GRALRDLDHV LQEALGDGDL PRRAEDFCRQ GRLLLSLGDE AAAAGAFAQA LKLAPSLAQN SLCRQPGRAP TARMFLLRGQ CCLEEQRHAE AWTAVESGLL VDPDHRGLKR LKARIRREAS SGCWLQ
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