Potassium channel subfamily U member 1 (KCNU1)

About Potassium channel subfamily U member 1

Potassium channel subfamily U member 1 (KCNU1) is a protein from Homo sapiens identified by UniProt accession A8MYU2, 1149 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.

Target properties

Protein name	Potassium channel subfamily U member 1
UniProt accession	A8MYU2
Gene	KCNU1
Organism	Homo sapiens
Length	1149 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (124)

Diseases linked to this target (Open Targets).

body fat percentage · score 0.43
breast carcinoma · score 0.42
triglyceride measurement · score 0.40
type 2 diabetes mellitus · score 0.40
sex hormone-binding globulin measurement · score 0.39
high density lipoprotein cholesterol measurement · score 0.38
breast size · score 0.38
age at first sexual intercourse measurement · score 0.37
mammographic density measurement · score 0.36
reticulocyte count · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A8MYU2-F1	alphafold	PREDICTED	74.23	—

Amino-acid sequence (1149 residues)

MFQTKLRNET WEDLPKMSCT TEIQAAFILS SFVTFFSGLI ILLIFRLIWR SVKKWQIIKG TGIILELFTS GTIARSHVRS LHFQGQFRDH IEMLLSAQTF VGQVLVILVF VLSIGSLIIY FINSADPVGS CSSYEDKTIP IDLVFNAFFS FYFGLRFMAA DDKIKFWLEM NSIVDIFTIP PTFISYYLKS NWLGLRFLRA LRLLELPQIL QILRAIKTSN SVKFSKLLSI ILSTWFTAAG FIHLVENSGD PWLKGRNSQN ISYFESIYLV MATTSTVGFG DVVAKTSLGR TFIMFFTLGS LILFANYIPE MVELFANKRK YTSSYEALKG KKFIVVCGNI TVDSVTAFLR NFLRDKSGEI NTEIVFLGET PPSLELETIF KCYLAYTTFI SGSAMKWEDL RRVAVESAEA CLIIANPLCS DSHAEDISNI MRVLSIKNYD STTRIIIQIL QSHNKVYLPK IPSWNWDTGD NIICFAELKL GFIAQGCLVP GLCTFLTSLF VEQNKKVMPK QTWKKHFLNS MKNKILTQRL SDDFAGMSFP EVARLCFLKM HLLLIAIEYK SLFTDGFCGL ILNPPPQVRI RKNTLGFFIA ETPKDVRRAL FYCSVCHDDV FIPELITNCG CKSRSRQHIT VPSVKRMKKC LKGISSRISG QDSPPRVSAS TSSISNFTTR TLQHDVEQDS DQLDSSGMFH WCKPTSLDKV TLKRTGKSKY KFRNHIVACV FGDAHSAPMG LRNFVMPLRA SNYTRKELKD IVFIGSLDYL QREWRFLWNF PQIYILPGCA LYSGDLHAAN IEQCSMCAVL SPPPQPSSNQ TLVDTEAIMA TLTIGSLQID SSSDPSPSVS EETPGYTNGH NEKSNCRKVP ILTELKNPSN IHFIEQLGGL EGSLQETNLH LSTAFSTGTV FSGSFLDSLL ATAFYNYHVL ELLQMLVTGG VSSQLEQHLD KDKVYGVADS CTSLLSGRNR CKLGLLSLHE TILSDVNPRN TFGQLFCGSL DLFGILCVGL YRIIDEEELN PENKRFVITR PANEFKLLPS DLVFCAIPFS TACYKRNEEF SLQKSYEIVN KASQTTETHS DTNCPPTIDS VTETLYSPVY SYQPRTNSLS FPKQIAWNQS RTNSIISSQI PLGDNAKENE RKTSDEVYDE DPFAYSEPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards