Doublecortin domain-containing protein 2C (DCDC2C)

About Doublecortin domain-containing protein 2C

Doublecortin domain-containing protein 2C (DCDC2C) is a protein from Homo sapiens identified by UniProt accession A8MYV0, 364 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Doublecortin domain-containing protein 2C
UniProt accession	A8MYV0
Gene	DCDC2C
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

ceramide measurement · score 0.32
adolescent idiopathic scoliosis · score 0.17
methylmalonic aciduria and homocystinuria type cblC · score 0.12
Methylmalonic acidemia with homocystinuria, type cblC · score 0.12
Methylmalonic acidemia with homocystinuria · score 0.12
restless legs syndrome · score 0.11
dental caries · score 0.09
autosomal recessive spondylocostal dysostosis · score 0.06
self reported educational attainment · score 0.06
cervical spondylosis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A8MYV0-F1	alphafold	PREDICTED	70.43	—

Amino-acid sequence (364 residues)

MGTRGPSAPV DTTPAKTIVV YRNGDPFYVG KKFVLSRRRA ATFEALLEQL TEQVDVPFGV RRLFTPTRGH RVLGLDALQA GGKYVAAGRE RFKELDYIHI VPRKPAKIRK LKEIKPVVHC DINVPSKWQT YHRISRHINV FTNGRLFIPP AKIIIPKFSL SDWDIVLATI GEKVFPLGGV RKLFTMNGHL LGDSKDLQDN HFYVAVGLET FKYFPYWKSP RVPSEVQQRY ANVEKNSQRK KKVDSKGKEP CKYDGIPPKT QDSVYYAKEE KKKTLAEPLV QRGAEGDVYK APTPSKETQG ALDVKEEHNV QLEVPVDQRQ AEIVKEDEEI HENTPDFEGN KDKEDARLCE DVERKMAREW KPVD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards