EF-hand calcium-binding domain-containing protein 9…

About EF-hand calcium-binding domain-containing protein 9

EF-hand calcium-binding domain-containing protein 9 (EFCAB9) is a protein from Homo sapiens identified by UniProt accession A8MZ26, 197 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.

Target properties

Protein name	EF-hand calcium-binding domain-containing protein 9
UniProt accession	A8MZ26
Gene	EFCAB9
Organism	Homo sapiens
Length	197 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (73)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.12
azoospermia · score 0.10
heel bone mineral density · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.09
3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.08
neurofibrillary tangles measurement · score 0.07
spermatogenic failure 72 · score 0.06
spermatogenic failure 46 · score 0.06
spermatogenic failure 18 · score 0.06
spermatogenic failure 27 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A8MZ26-F1	alphafold	PREDICTED	94.02	—

Amino-acid sequence (197 residues)

MRLKQGSFLW YLYLDKIYCL LSVRNVKALA EYFHILDVHG KNTLNDVLFY HFLHHVTDLK KAQINIVFDM LDWNAVGEID FEKFYMLVCM LLAHQNHLEG QFMYRHSRPV FDLLDLKGDL RIGAKNFEMY RFLFNIQKQE LKDLFRDFDI TGDNRLNYQE FKLYTIIYTD KLQKRQKTEE KEKGERKRSL YSKCHIK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

EF-hand calcium-binding domain-containing protein 9 (EFCAB9)