About Paired-like homeodomain transcription factor LEUTX
Paired-like homeodomain transcription factor LEUTX (LEUTX) is a protein
from Homo sapiens identified by UniProt accession
A8MZ59, 198 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | Paired-like homeodomain transcription factor LEUTX |
|---|
| UniProt accession | A8MZ59 |
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| Gene | LEUTX |
|---|
| Organism | Homo sapiens |
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| Length | 198 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (19)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.02
- acute myeloid leukemia · score 0.02
- Central Nervous System Neoplasm · score 0.02
- blood protein measurement · score 0.02
- sarcoma · score 0.02
- Facioscapulohumeral dystrophy · score 0.01
- Bartsocas-Papas syndrome 1 · score 0.01
- myeloid leukemia · score 0.01
- alveolar rhabdomyosarcoma · score 0.01
- facioscapulohumeral muscular dystrophy · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MZ59-F1 | alphafold | PREDICTED | 67.52 | — |
Amino-acid sequence (198 residues)
MFEGPRRYRR PRTRFLSKQL TALRELLEKT MHPSLATMGK LASKLQLDLS VVKIWFKNQR AKWKRQQRQQ MQTRPSLGPA NQTTSVKKEE TPSAITTANI RPVSPGISDA NDHDLREPSG IKNPGGASAS ARVSSWDSQS YDIEQICLGA SNPPWASTLF EIDEFVKIYD LPGEDDTSSL NQYLFPVCLE YDQLQSSV
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